… produce analgesia by … opioid receptors in analgesia with special focus on novel pharmaceutical
concepts for the clinical use of exogenous and endogenous peripheral opioid analgesia. …

… Peripheral opioid receptors and inflammation Peripheral opioid analgesic effects have
been … of receptors and receptor upregulation on peripheral nerve terminals is observed (for …

… analgesic agents devoid of central side effects. The presence of different types of peripheral
opioid … In summary, peripheral opioid analgesic effects require more extensively controlled …

… mechanisms underlying peripheral opioid analgesic effects such as localization, trafficking
and function of peripheral opioid receptors and the production and release of opioid peptides …

… the CNS, producing analgesia by interaction with cerebral and spinal opioid receptors. This
… of peripheral opioid receptors to opioid analgesia. Local injection of opioids into peripheral …

… In summary, the present view of peripheral opioid analgesia offers a variety of different
facets; the mechanisms underlying them are presently only partly understood; their further …

… peripheral opioid receptors, production and release of opioid peptides from inflammatory cells,
as well as analgesia… brought about by peripherally acting opioids. Thereafter, interactions …

… In summary, we have shown that peripheral opioid analgesia and perineurial disruption …
(1) While initially discovered under inflammatory conditions, peripheral opioid analgesic effects …

… Targeting peripheral opioid receptors became an area of renewed interest. While earlier
attempts to demonstrate peripheral opioid analgesia in healthy tissue failed, potent …

… view that opioid antinociception is mediated exclusively within the central nervous system,
peripheral opioid receptors have been discovered and shown to mediate analgesic effects …