Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims

P Zill, A Büttner, W Eisenmenger, HJ Möller, B Bondy… - Biological …, 2004 - Elsevier
BACKGROUND: Tryptophan hydroxylase, the rate-limiting enzyme in the biosynthesis of
serotonin, represents a major candidate in numerous genetic association analyses of …
被引用次数：282 相关文章 所有 11 个版本
[PDF] academia.edu

Suicide attempts and the tryptophan hydroxylase gene

M Abbar, P Courtet, F Bellivier, M Leboyer… - Molecular …, 2001 - nature.com
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme of serotonin synthesis. In this case-
control study, we investigated whether the TPH gene was a susceptibility factor for suicidal …
被引用次数：153 相关文章 所有 15 个版本

Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide

L Ke, ZY Qi, Y Ping, CY Ren - Brain research, 2006 - Elsevier
Objective: The novel tryptophan hydroxylase isoform (TPH2), being the rate-limiting enzyme
in the biosynthesis of serotonin, has many biological functions and plays an important role …
被引用次数：89 相关文章 所有 11 个版本
[PDF] academia.edu

TPH and suicidal behavior: a study in suicide completers

G Turecki, Z Zhu, J Tzenova, A Lesage, M Séguin… - Molecular …, 2001 - nature.com
An association between the gene that codes for tryptophan hydroxylase (TPH)—the rate-
limiting enzyme in the synthesis of serotonin—and suicidal behavior has been investigated …
被引用次数：112 相关文章 所有 14 个版本

Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis

D Rujescu, I Giegling, T Sato, AM Hartmann… - Biological …, 2003 - Elsevier
BACKGROUND: Neurobiological studies implicate serotonergic dysfunction in suicidal
behavior. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of …
被引用次数：172 相关文章 所有 9 个版本

Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors

SJ Tsai, CJ Hong, YC Wang - Neuroreport, 1999 - journals.lww.com
SEROTONERGIC dysfunction is implicated in mood disorders and suicidal behaviors.
Genetic variants of tryptophan hydroxylase (TPH), a rate-limiting enzyme in the biosynthesis …
被引用次数：107 相关文章 所有 7 个版本
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The tryptophan hydroxylase 1 (TPH1) gene, schizophrenia susceptibility, and suicidal behavior: A multicentre case–control study and metaanalysis

P Saetre, P Lundmark, A Wang… - American Journal of …, 2010 - Wiley Online Library
Abstract Serotonin (5hydroxytryptamin; 5HT) alternations has since long been suspected
in the pathophysiology of schizophrenia. Tryptophan hydroxylase (tryptophan 5 …
被引用次数：74 相关文章 所有 15 个版本

Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses

D Li, L He - Human genetics, 2006 - Springer
Suicide is a major public health issue, especially in western countries, accounting for
approximately 1 million deaths every year throughout the world. The tryptophan hydroxylase …
被引用次数：142 相关文章 所有 12 个版本
[PDF] academia.edu

Tryptophan hydroxylase immunoreactivity is altered by the genetic variation in postmortem brain samples of both suicide victims and controls

H Ono, O Shirakawa, N Kitamura, T Hashimoto… - Molecular …, 2002 - nature.com
Several lines of evidence suggest that a partly genetically controlled serotonergic
dysfunction is involved in the biological pathogenesis of suicide. In this study, we measured …
被引用次数：81 相关文章 所有 11 个版本
[PDF] nature.com

SNP-and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide

P Zill, UW Preuss, G Koller, B Bondy… - …, 2007 - nature.com
Several lines of evidence indicate that disturbances of the central serotonergic system are
involved in the pathophysiology of alcohol dependence and suicidal behavior. Recent …
被引用次数：60 相关文章 所有 10 个版本