Purpose: The objective of this study it to use a novel chondrogenic and anti-inflammatory
growth factor, progranulin (PGRN), with external Low Intensity Pulsed Ultrasound (LIPUS) as …

Objectives Cartilage is a highly mechano-responsive tissue. Chondrocytes undergo a series
of complex changes, including proliferation and metabolic alteration as the target of external …

Low-intensity pulsed ultrasound (LIPUS) is used for bone healing in orthopedics. In previous
in vivo and in vitro studies, LIPUS has been shown to have promising effects on cellular …

Lowintensity pulsed ultrasound (LIPUS), a noninvasive physical therapy, was recently
demonstrated to be an effective treatment for osteoarthritis (OA). Vascular endothelium …

We investigated whether low-intensity pulsed ultrasound (LIPUS) stimulates chondrocyte
proliferation and matrix production in explants of human articular cartilage obtained from …

The effect of low-intensity pulsed ultrasound (LIPUS) on articular cartilage metabolism has
been characterized. However, the effect of LIPUS intensity on articular cartilage degradation …

Objective To investigate the effect of low-intensity pulsed ultrasound (LIPUS) on the
extracellular matrix synthesis of human osteoarthritis (OA) chondrocytes and explore the …

Low-intensity pulsed ultrasound (LIPUS) has been shown to accelerate fracture healing, but
the precise mechanism is still unknown. We used aggregate chondrocyte culture system to …

In this study, the effect of lowintensity pulsed ultrasound (LIPUS) on cartilage was
evaluated in a rat osteoarthritis (OA) model using serum biomarkers such as CTXII (type II …

Although low-intensity pulsed ultrasound (LIPUS) regulates p38 mitogen-activated protein
kinase (MAPK) and promotes cartilage repair in osteoarthritis, the role of integrin-mediated …