Time to abandon the bio-bio-bio model of psychosis: Exploring the epigenetic and psychological mechanisms by which adverse life events lead to psychotic …
Mental health services and research have been dominated for several decades by a rather
simplistic, reductionistic focus on biological phenomena, with minimal consideration of the …
simplistic, reductionistic focus on biological phenomena, with minimal consideration of the …
Childhood trauma as a cause of psychosis: linking genes, psychology, and biology
R Van Winkel, M Van Nierop… - The Canadian …, 2013 - journals.sagepub.com
Recent studies have provided robust evidence for an association between childhood trauma
(CT) and psychosis. Meta-analyses have quantified the association, pointing to odds ratios …
(CT) and psychosis. Meta-analyses have quantified the association, pointing to odds ratios …
The traumagenic neurodevelopmental model of psychosis revisited
Evidence that childhood adversities are risk factors for psychosis has accumulated rapidly.
Research into the mechanisms underlying these relationships has focused, productively, on …
Research into the mechanisms underlying these relationships has focused, productively, on …
Bad things happen and can drive you crazy
Studies consistently Ūnd that while members of the public understand that many factors
inŊuence our mental health, they place much more emphasis on adverse life events than on …
inŊuence our mental health, they place much more emphasis on adverse life events than on …
Toward a unified theory of childhood trauma and psychosis: a comprehensive review of epidemiological, clinical, neuropsychological and biological findings
B Misiak, M Krefft, T Bielawski, AA Moustafa… - Neuroscience & …, 2017 - Elsevier
There is a growing body of research focused on the relationship between childhood trauma
and the risk of developing psychosis. Numerous studies, including many large-scale …
and the risk of developing psychosis. Numerous studies, including many large-scale …
Child maltreatment and psychosis: a return to a genuinely integrated bio-psycho-social model
J Read, P Fink, T Rudegeair… - Clinical …, 2008 - meridian.allenpress.com
For several decades the conceptualization and treatment of mental health problems,
including psychosis, have been dominated by a rather narrow focus on genes and brain …
including psychosis, have been dominated by a rather narrow focus on genes and brain …
Psychosis as a transdiagnostic and extended phenotype in the general population
J Van Os, U Reininghaus - World Psychiatry, 2016 - Wiley Online Library
A large body of research indicates that weak expressions of positive psychotic symptoms
(“psychotic experiences”) can be measured in the general population, and likely represent …
(“psychotic experiences”) can be measured in the general population, and likely represent …
Epigenetic mediation of environmental influences in major psychotic disorders
BPF Rutten, J Mill - Schizophrenia bulletin, 2009 - academic.oup.com
The major psychotic disorders schizophrenia and bipolar disorder are etiologically complex
involving both heritable and nonheritable factors. The absence of consistently replicated …
involving both heritable and nonheritable factors. The absence of consistently replicated …
Gene–environment interplay in the etiology of psychosis
Schizophrenia and other types of psychosis incur suffering, high health care costs and loss
of human potential, due to the combination of early onset and poor response to treatment …
of human potential, due to the combination of early onset and poor response to treatment …
The daunting polygenicity of mental illness: making a new map
SE Hyman - … Transactions of the Royal Society B …, 2018 - royalsocietypublishing.org
An epochal opportunity to elucidate the pathogenic mechanisms of psychiatric disorders has
emerged from advances in genomic technology, new computational tools and the growth of …
emerged from advances in genomic technology, new computational tools and the growth of …