Time to abandon the bio-bio-bio model of psychosis: Exploring the epigenetic and psychological mechanisms by which adverse life events lead to psychotic …

J Read, RP Bentall, R Fosse - Epidemiology and Psychiatric …, 2009 - cambridge.org
Mental health services and research have been dominated for several decades by a rather
simplistic, reductionistic focus on biological phenomena, with minimal consideration of the …

Childhood trauma as a cause of psychosis: linking genes, psychology, and biology

R Van Winkel, M Van Nierop… - The Canadian …, 2013 - journals.sagepub.com
Recent studies have provided robust evidence for an association between childhood trauma
(CT) and psychosis. Meta-analyses have quantified the association, pointing to odds ratios …

The traumagenic neurodevelopmental model of psychosis revisited

J Read, R Fosse, A Moskowitz, B Perry - Neuropsychiatry, 2014 - pure.au.dk
Evidence that childhood adversities are risk factors for psychosis has accumulated rapidly.
Research into the mechanisms underlying these relationships has focused, productively, on …

Bad things happen and can drive you crazy

J Read, N Haslam - Models of madness: Psychological, social …, 2004 - books.google.com
Studies consistently Ūnd that while members of the public understand that many factors
inŊuence our mental health, they place much more emphasis on adverse life events than on …

Toward a unified theory of childhood trauma and psychosis: a comprehensive review of epidemiological, clinical, neuropsychological and biological findings

B Misiak, M Krefft, T Bielawski, AA Moustafa… - Neuroscience & …, 2017 - Elsevier
There is a growing body of research focused on the relationship between childhood trauma
and the risk of developing psychosis. Numerous studies, including many large-scale …

Child maltreatment and psychosis: a return to a genuinely integrated bio-psycho-social model

J Read, P Fink, T Rudegeair… - Clinical …, 2008 - meridian.allenpress.com
For several decades the conceptualization and treatment of mental health problems,
including psychosis, have been dominated by a rather narrow focus on genes and brain …

Psychosis as a transdiagnostic and extended phenotype in the general population

J Van Os, U Reininghaus - World Psychiatry, 2016 - Wiley Online Library
A large body of research indicates that weak expressions of positive psychotic symptoms
(“psychotic experiences”) can be measured in the general population, and likely represent …

Epigenetic mediation of environmental influences in major psychotic disorders

BPF Rutten, J Mill - Schizophrenia bulletin, 2009 - academic.oup.com
The major psychotic disorders schizophrenia and bipolar disorder are etiologically complex
involving both heritable and nonheritable factors. The absence of consistently replicated …

Gene–environment interplay in the etiology of psychosis

A Zwicker, EM Denovan-Wright, R Uher - Psychological medicine, 2018 - cambridge.org
Schizophrenia and other types of psychosis incur suffering, high health care costs and loss
of human potential, due to the combination of early onset and poor response to treatment …

The daunting polygenicity of mental illness: making a new map

SE Hyman - … Transactions of the Royal Society B …, 2018 - royalsocietypublishing.org
An epochal opportunity to elucidate the pathogenic mechanisms of psychiatric disorders has
emerged from advances in genomic technology, new computational tools and the growth of …