Background Tranexamic acid can reduce bleeding in patients undergoing elective surgery.
We assessed the effects of early administration of a short course of tranexamic acid on …

Background Tranexamic acid can reduce bleeding in patients undergoing elective surgery.
We assessed the effects of early administration of a short course of tranexamic acid on …

This important paper addressed a key clinical question, which was exceptionally novel at the
time of investigation. Namely, could the early administration of 1 gram of tranexamic acid …

Background A reduction in mortality with the early use of tranexamic acid has been
demonstrated in severely injured patients who are bleeding. However, the modest treatment …

BACKGROUND: The aim of the CRASH-2 trial was to assess the effects of early
administration of tranexamic acid on death, vascular occlusive events, and blood transfusion …

Objectives To examine whether the effect of tranexamic acid on the risk of death and
thrombotic events in patients with traumatic bleeding varies according to baseline risk of …

Background The CRASH-2 trial showed that tranexamic acid (TXA) administration reduces
mortality in bleeding trauma patients. However, the effect appeared to depend on how soon …

Results All cause mortality was significantly reduced in the tranexamic acid group (1,463
[14.5%] compared with the placebo group 1,613 [16.0%]; relative risk 0.91, 95% CI 0.85 …

Background Each year, worldwide, about 3 million people die as a result of trauma, many
after reaching hospital. Among trauma patients who do survive to reach hospital, bleeding is …

Uncontrolled hemorrhage causes 30%–45% of all trauma-related deaths. The Clinical
Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH-2) trial, an …