Rapid Responses and Mechanism of Action for Low-Dose Bisphenol S on ex Vivo Rat Hearts and Isolated Myocytes: Evidence of Female-Specific Proarrhythmic …

X Gao, J Ma, Y Chen, HS Wang - Environmental health …, 2015 - ehp.niehs.nih.gov
Background Bisphenol S (BPS) has increasingly been used as a substitute for bisphenol A
(BPA) in some “BPA-free” consumer goods and in thermal papers. Wide human exposure to …

Cellular mechanism of the nonmonotonic dose response of bisphenol A in rat cardiac myocytes

Q Liang, X Gao, Y Chen, K Hong… - Environmental health …, 2014 - ehp.niehs.nih.gov
Background: The need for mechanistic understanding of nonmonotonic dose responses has
been identified as one of the major data gaps in the study of bisphenol A (BPA). Previously …

Low-dose bisphenol A and estrogen increase ventricular arrhythmias following ischemia–reperfusion in female rat hearts

S Yan, W Song, Y Chen, K Hong, J Rubinstein… - Food and chemical …, 2013 - Elsevier
Bisphenol A (BPA) is an environmental estrogenic endocrine disruptor that may have
adverse health impacts on a range of tissue/systems. In previous studies, we reported that …

Molecular mechanisms underlying the rapid arrhythmogenic action of bisphenol A in female rat hearts

X Gao, Q Liang, Y Chen, HS Wang - Endocrinology, 2013 - academic.oup.com
Previously we showed that bisphenol A (BPA), an environmental estrogenic endocrine
disruptor, rapidly altered Ca2+ handling and promoted arrhythmias in female rat hearts. The …

Bisphenol A and 17β-estradiol promote arrhythmia in the female heart via alteration of calcium handling

S Yan, Y Chen, M Dong, W Song, SM Belcher… - PloS one, 2011 - journals.plos.org
Background There is wide-spread human exposure to bisphenol A (BPA), a ubiquitous
estrogenic endocrine disruptor that has been implicated as having potentially harmful effects …

Bisphenol A exposure and cardiac electrical conduction in excised rat hearts

NG Posnack, R Jaimes III, H Asfour… - Environmental …, 2014 - ehp.niehs.nih.gov
Background: Bisphenol A (BPA) is used to produce polycarbonate plastics and epoxy resins
that are widely used in everyday products, such as food and beverage containers, toys, and …

Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology, as compared with bisphenol A

TM Prudencio, LM Swift, D Guerrelli… - Toxicological …, 2021 - academic.oup.com
Bisphenol A (BPA) is a high-production volume chemical used to manufacture consumer
and medical-grade plastic products. Due to its ubiquity, the general population can incur …

Proarrhythmic toxicity of low dose bisphenol A and its analogs in human iPSC-derived cardiomyocytes and human cardiac organoids through delay of cardiac …

J Ma, NY Wang, R Jagani, HS Wang - Chemosphere, 2023 - Elsevier
Bisphenol A (BPA) and its analogs are common environmental chemicals with many
potential adverse health effects. The impact of environmentally relevant low dose BPA on …

Progesterone protects against bisphenol A–induced arrhythmias in female rat cardiac myocytes via rapid signaling

J Ma, K Hong, HS Wang - Endocrinology, 2017 - academic.oup.com
Bisphenol A (BPA) is an estrogenic endocrine-disrupting chemical (EDC) that has a range of
potential adverse health effects. Previously we showed that acute exposure to BPA …

Characteristics of bisphenol cardiotoxicity: impaired excitability, contractility, and relaxation

BL Cooper, NG Posnack - Cardiovascular toxicology, 2022 - Springer
Bisphenol a (BPA) is a high production volume chemical that is frequently used to
manufacture epoxy resins and polycarbonate plastics. BPA-containing products are now …