Epicardial adipose tissue GLP-1 receptor is associated with genes involved in fatty acid oxidation and white-to-brown fat differentiation: a target to modulate …

E Dozio, E Vianello, AE Malavazos, L Tacchini… - International journal of …, 2019 - Elsevier
Background Epicardial adipose tissue (EAT) is a risk factor for cardiovascular diseases.
Glucagon-like peptide 1 analogs (GLP-1A) may have beneficial cardiovascular effects and …

Human epicardial fat expresses glucagon-like peptide 1 and 2 receptors genes

G Iacobellis, V Camarena, DW Sant… - Hormone and …, 2017 - thieme-connect.com
Epicardial adipose tissue (EAT) is an easily measurable visceral fat of the heart with unique
anatomy, functionality, and transcriptome. EAT can serve as a therapeutic target for …

Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of …

AE Malavazos, G Iacobellis, E Dozio… - European journal of …, 2023 - academic.oup.com
Aims Human epicardial adipose tissue (EAT) plays a crucial role in the development and
progression of coronary artery disease, atrial fibrillation, and heart failure. Microscopically …

Cardiovascular risk reduction throughout GLP-1 receptor agonist and SGLT2 inhibitor modulation of epicardial fat

G Iacobellis, MG Baroni - Journal of endocrinological investigation, 2022 - Springer
Epicardial adipose tissue is a novel cardiovascular risk factor. It plays a role in the
progression of coronary artery disease, heart failure and atrial fibrillation. Given its rapid …

Effects of semaglutide versus dulaglutide on epicardial fat thickness in subjects with type 2 diabetes and obesity

G Iacobellis, AC Villasante Fricke - Journal of the Endocrine …, 2020 - academic.oup.com
Abstract Background and Aims Epicardial adipose tissue (EAT), the visceral fat depot of the
heart, is a modifiable cardio-metbolic risk factor and therapeutic target. Semaglutide and …

Epicardial adipose tissue in contemporary cardiology

G Iacobellis - Nature reviews cardiology, 2022 - nature.com
Interest in epicardial adipose tissue (EAT) is growing rapidly, and research in this area
appeals to a broad, multidisciplinary audience. EAT is unique in its anatomy and …

Expression of the receptor for advanced glycation end products in epicardial fat: link with tissue thickness and local insulin resistance in coronary artery disease

E Dozio, E Vianello, S Briganti, J Lamont… - Journal of Diabetes …, 2016 - Wiley Online Library
Increased expression of receptor for advanced glycation end products (RAGE) in adipose
tissue has been associated with inflammation, adipocyte hypertrophy, and impaired insulin …

Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease

EA McAninch, TL Fonseca, R Poggioli, AL Panos… - …, 2015 - Wiley Online Library
Objective To explore the transcriptome of epicardial adipose tissue (EAT) as compared to
subcutaneous adipose tissue (SAT) and its modifications in a small number of patients with …

Impaired cardiometabolic responses to glucagon-like peptide 1 in obesity and type 2 diabetes mellitus

SP Moberly, KJ Mather, ZC Berwick, MK Owen… - Basic research in …, 2013 - Springer
Abstract Glucagon-like peptide 1 (GLP-1) has insulin-like effects on myocardial glucose
uptake which may contribute to its beneficial effects in the setting of myocardial ischemia …

Epicardial fat links obesity to cardiovascular diseases

G Iacobellis - Progress in cardiovascular diseases, 2023 - Elsevier
Patients with obesity have been historically associated with higher risk to develop
cardiovascular diseases (CVD). However, regional, visceral, organ specific adiposity seems …