Identification of genes associated with hereditary cancers facilitates management of patients
with family histories of cancer. We performed exome sequencing of DNA from 3 individuals …

Colorectal cancer (CRC) is one of the most common neoplasms in the world. Fanconi
anemia (FA) is a very rare genetic disease causing bone marrow failure, congenital growth …

Background & Aims: How specifically to treat pancreatic and other cancers harboring
Fanconi anemia gene mutations has raised great interest recently, yet preclinical studies …

Fanconi anemia is a human cancer predisposition syndrome caused by mutations in 13
Fanc genes. The disorder is characterized by genomic instability and cellular …

Patients with Fanconi anemia (FA) display a wide variety of defects including bone marrow
failure and a high risk of developing cancer. Multiple Fanconi genes exist whose proteins …

Purpose Mutations in genes involved in Fanconi anemia (FA)/BRCA DNA repair pathway
cause cancer susceptibility diseases including familial breast cancer and Fanconi anemia …

Human cancers exhibit genomic instability and an increased mutation rate due to underlying
defects in DNA repair. Cancer cells are often defective in one of six major DNA repair …

Fanconi anemia (FA) is caused by biallelic mutations in FA genes. Monoallelic mutations in
five of these genes (BRCA1, BRCA2, PALB2, BRIP1 and RAD51C) increase the …

Fanconi anemia (FA) is a complex genetic disorder characterized by bone marrow failure
(BMF), congenital defects, inability to repair DNA interstrand cross-links (ICLs), and cancer …

Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the
BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination …