Longitudinal changes in brain oxygen extraction fraction (OEF) in older adults: Relationship to markers of vascular and Alzheimer's pathology
Introduction Oxygen extraction fraction (OEF) reflects the balance between oxygen delivery
and consumption. We longitudinally measured OEF in older adults to examine the …
and consumption. We longitudinally measured OEF in older adults to examine the …
Brain oxygen extraction is differentially altered by Alzheimer's and vascular diseases
Background Alzheimer's disease and vascular cognitive impairment (VCI), as well as their
concurrence, represent the most common types of cognitive dysfunction. Treatment …
concurrence, represent the most common types of cognitive dysfunction. Treatment …
Lower cerebral oxygen utilization is associated with Alzheimer's disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 …
Oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) are
markers of cerebral oxygen homeostasis and metabolism that may offer insights into …
markers of cerebral oxygen homeostasis and metabolism that may offer insights into …
Brain oxygen extraction by using MRI in older individuals: relationship to apolipoprotein E genotype and amyloid burden
Background Apolipoprotein E4 (APOE4) is a major genetic risk factor for late-onset
Alzheimer disease. However, the mechanisms by which APOE4 affects the brain …
Alzheimer disease. However, the mechanisms by which APOE4 affects the brain …
Brain oxygen extraction and neural tissue susceptibility are associated with cognitive impairment in older individuals
Abstract Background and Purpose We investigated the effects of aging, white matter
hyperintensities (WMH), and cognitive impairment on brain iron levels and cerebral oxygen …
hyperintensities (WMH), and cognitive impairment on brain iron levels and cerebral oxygen …
Vascular and metabolic reserve in Alzheimer's disease
K Nagata, Y Kondoh, R Atchison, M Sato, Y Satoh… - Neurobiology of …, 2000 - Elsevier
Vascular and metabolic reserve were analyzed in probable Alzheimer's disease (AD) and
vascular dementia (VaD). Cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral …
vascular dementia (VaD). Cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral …
Reduced global brain metabolism but maintained vascular function in amnestic mild cognitive impairment
Amnestic mild cognitive impairment represents an early stage of Alzheimer's disease, and
characterization of physiological alterations in mild cognitive impairment is an important step …
characterization of physiological alterations in mild cognitive impairment is an important step …
[HTML][HTML] Evaluation of whole-brain oxygen metabolism in Alzheimer's disease using QSM and quantitative BOLD
Objective The objective of this study was to evaluate the whole-brain pattern of oxygen
extraction fraction (OEF), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen …
extraction fraction (OEF), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen …
[HTML][HTML] Application of calibrated fMRI in Alzheimer's disease
Calibrated fMRI based on arterial spin-labeling (ASL) and blood oxygen-dependent contrast
(BOLD), combined with periods of hypercapnia and hyperoxia, can provide information on …
(BOLD), combined with periods of hypercapnia and hyperoxia, can provide information on …
Oxygen metabolic stress and white matter injury in patients with cerebral small vessel disease
Background: Chronic hypoxia-ischemia is a putative mechanism underlying the
development of white matter hyperintensities (WMH) and microstructural disruption in …
development of white matter hyperintensities (WMH) and microstructural disruption in …