Cigarette smoke, containing both nicotine and carcinogens, causes lung cancer. However,
not all smokers develop lung cancer, highlighting the importance of the interaction between …

Metabolism of nicotine by cytochrome P450 2A6 (CYP2A6) is a suspected determinant of
smoking dose and, consequently, lung cancer risk. We conducted a genome-wide …

Abstract Cytochrome P450 2A6 (CYP2A6) is an enzyme involved in the metabolism of some
tobacco carcinogens, which is an important risk factor of lung cancer. Among CYP2A6 allelic …

Cytochrome P4501A2 (CYP1A2) is a key enzyme for lung carcinogen activation and lung
inflammation. We studied the interactions of the CYP1A2 functional variants-3860 G/A …

Background: The impact of genetic polymorphisms in CYP1A1 or CYP1B1 on susceptibility
to lung cancer has received particular attention since these enzymes play a central role in …

This study aimed to identify new genetic characteristics contributing to individual
susceptibility to smoke-induced lung cancer. Despite functional evidence of a possible role …

Abstract Cytochrome P450 2A6 (CYP2A6) is an enzyme responsible for the metabolism of
nicotine and some tobacco‐specific carcinogens (such as N‐nitrosamines). CYP2A6 genetic …

Genetic variation in cytochrome P450 2A6 (CYP2A6) gene is the primary contributor to the
intraindividual and interindividual differences in nicotine metabolism and has been found to …

CYP24A1 plays important roles in antiproliferative effects, which have been proved in many
human tumor cells. Polymorphisms in CYP24A1 may affect the risk of lung cancer, but the …

We investigated genetic variation in CYP2A6 in relation to lung cancer risk among African
American smokers, a high-risk population. Previously, we found that CYP2A6, a …