Update on Fc receptor-like (FCRL) family: new immunoregulatory players in health and diseases
Introduction: Fc receptor-like (FCRL) molecules, as recently identified members of the
immunoglobulin superfamily (IgSF), are preferentially expressed by B-cells. They have …
immunoglobulin superfamily (IgSF), are preferentially expressed by B-cells. They have …
Cutting edge: human FcRL4 and FcRL5 are receptors for IgA and IgG
TJ Wilson, A Fuchs, M Colonna - The Journal of Immunology, 2012 - journals.aai.org
Fc receptor-like (FcRL) proteins are a family of cellular receptors homologous to FcγRI and
are predominantly expressed by B cells. They function to costimulate or inhibit BCR …
are predominantly expressed by B cells. They function to costimulate or inhibit BCR …
Emerging roles for the FCRL family members in lymphocyte biology and disease
Members of the extended Fc receptor-like (FCRL) family in humans and mice are
preferentially expressed by B cells and possess tyrosine-based immunoregulatory function …
preferentially expressed by B cells and possess tyrosine-based immunoregulatory function …
[HTML][HTML] Fc receptor-like proteins in pathophysiology of B-cell disorder
M Capone, JM Bryant, N Sutkowski… - Journal of clinical & …, 2016 - ncbi.nlm.nih.gov
Members of the family of Fc receptor-like (FcRL) proteins, homologous to FcγRI, have been
identified by multiple research groups. Consequently, they have been described using …
identified by multiple research groups. Consequently, they have been described using …
Immunoregulatory roles for fc receptor-like molecules
GRA Ehrhardt, MD Cooper - Negative Co-Receptors and Ligands, 2011 - Springer
Fc receptor-like (FCRL) molecules comprise a family of imunoregulatory transmembrane
proteins that are preferentially, but not exclusively expressed on B lineage cells. A strong …
proteins that are preferentially, but not exclusively expressed on B lineage cells. A strong …
Fc receptor–like proteins (FCRL): immunomodulators of B cell function
GGRA Ehrhardt, CM Leu, S Zhang, G Aksu… - … of Lymphocyte Activation …, 2007 - Springer
The Fc receptor-like (FCRL) proteins belong to a recently identified group of type 1
immunoglobulin (Ig) superfamily orphan receptors. Five of the six FCRL family members are …
immunoglobulin (Ig) superfamily orphan receptors. Five of the six FCRL family members are …
Ligation of human Fc receptor like‐2 by monoclonal antibodies down‐regulates B‐cell receptor‐mediated signalling
B‐cell antigen receptor (BCR) signalling and its regulation through negative and positive
regulators are critical for balancing B‐cell response and function. Human Fc receptor like‐2 …
regulators are critical for balancing B‐cell response and function. Human Fc receptor like‐2 …
An extended family of Fc receptor relatives
RS Davis, GRA Ehrhardt, CM Leu… - European journal of …, 2005 - Wiley Online Library
A surprising number of Fc receptor (FcR) relatives have been recognized recently with the
potential capacity to modulate innate and adaptive immune responses. The six human FcR …
potential capacity to modulate innate and adaptive immune responses. The six human FcR …
Fc receptor-like 1 (FCRL1) is a novel biomarker for prognosis and a possible therapeutic target in diffuse large B-cell lymphoma
Background Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-
Hodgkin's lymphoma, which can involve various types of mature B-cells. Considering that …
Hodgkin's lymphoma, which can involve various types of mature B-cells. Considering that …
Signal regulators in FcR-mediated activation of leukocytes?
P Mina-Osorio, E Ortega - Trends in immunology, 2004 - cell.com
Leukocyte membrane receptors for the Fc portion of Igs (FcRs) link antigen recognition by
antibodies to effector functions involved in immune phenomena, from pathogen elimination …
antibodies to effector functions involved in immune phenomena, from pathogen elimination …