Abstract Motivation: Ancient DNA (aDNA) molecules in fossilized bones and teeth,
coprolites, sediments, mummified specimens and museum collections represent fantastic …

Contamination from present-day DNA is a fundamental issue when studying ancient DNA
from historical or archaeological material, and quantifying the amount of contamination is …

Post-mortem damage (PMD) obstructs the proper analysis of ancient DNA samples.
Currently, PMD can only be addressed by adjusting sequencing quality scores or by …

Motivation In ancient DNA research, the authentication of ancient samples based on specific
features remains a crucial step in data analysis. Because of this central importance …

Ancient DNA extracts consist of a mixture of contaminant DNA molecules, most often
originating from environmental microbes, and endogenous fragments exhibiting substantial …

Ancient DNA has emerged as a remarkable tool to infer the history of extinct species and
past populations. However, many of its characteristics, such as extensive fragmentation …

The persistence of DNA over archaeological and paleontological timescales in diverse
environments has led to a revolutionary body of paleogenomic research, yet the dynamics of …

DNA contamination arising from the manipulation of ancient calcified tissue samples is a
poorly understood, yet fundamental, problem that affects the reliability of ancient DNA …

Ancient DNA (aDNA) research has long depended on the power of PCR to amplify trace
amounts of surviving genetic material from preserved specimens. While PCR permits …

Abstract Background Next-Generation Sequencing has revolutionized our approach to
ancient DNA (aDNA) research, by providing complete genomic sequences of ancient …