Objectives This study investigates pathogenic and protective polyfunctional T-cell responses
in patient with rheumatoid arthritis (RA), individuals at risk (IAR) and healthy control (HC) …

One manifestation of rheumatoid arthritis (RA) is a destructive inflammation of the joint, but
many other organs can be targeted by this disease, classifying it as a truly systemic disorder …

Objective Recent studies have uncovered diverse cell types/states in the RA synovium;
however limited data exist correlating these findings with patient-level clinical information …

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing …

Rheumatoid arthritis (RA) is an autoimmune disease initiated by antigen-specific T cells and
B cells, which promote synovial inflammation through a complex set of interactions with …

Objectives Systemic immunological processes are profoundly shaped by the micro-
environments where antigen recognition occurs. Identifying molecular signatures distinctive …

Objective. To examine the compartment of CD4+ T cells in patients with rheumatoid arthritis
(RA) who have developed persistent lymphopenia following antibody‐mediated T cell …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation
of the synovial lining (synovitis). The inflammation in the RA joint is associated with and …

Objectives We explored histological and transcriptomic profiles of paired synovial biopsies
from rheumatoid arthritis (RA) patients, in order to assess homogeneity in synovial tissue at …

T cells, in particular CD4+ T cells, have been implicated in mediating many aspects of
autoimmune inflammation. However, current evidence suggests that the role played by …