Objectives Results from magnetic resonance imaging (MRI) studies are heterogeneous with
regard to hippocampal and amygdala volume alterations in bipolar disorder (BD). Lithium …

Objective Magnetic resonance imaging (MRI) studies in bipolar I disorder (BD‐I) suggest
that lithium is associated with increased volumes of cortico‐limbic structures. However, more …

BackgroundNeuroimaging studies have demonstrated an association between lithium (Li)
treatment and brain structure in human subjects. A crucial unresolved question is whether …

Background Prior studies on the effects of lithium on limbic and subcortical gray matter
volumes are mixed. It is possible that discrepant findings may be explained by the duration …

Background Lithium is one of the most effective medications for bipolar disorder episode
prevention, but its mechanism of action is still largely unknown. The hippocampus is a …

Rationale The majority of volumetric magnetic resonance imaging (MRI) studies of the
hippocampus in patients with bipolar disorder (BD) show no differences in hippocampal …

Objectives Patients diagnosed with bipolar disorder (BP) may experience hippocampal
atrophy. Lithium exposure has been associated with increased hippocampal volumes …

Hajek T, Cullis J, Novak T, Kopecek M, Höschl C, Blagdon R, O'Donovan C, Bauer M, Young
LT, MacQueen G, Alda M. Hippocampal volumes in bipolar disorders: opposing effects of …

Relative to healthy controls, lithium free bipolar patients exhibit significant gray matter
abnormalities. Lithium, the long-time reference standard medication treatment for bipolar …

Previous structural neuroimaging studies of bipolar disorder have reported conflicting
findings in limbic structures. Medication heterogeneity of patient samples may have …