[HTML][HTML] High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier
Nucleosomes represent mechanical and energetic barriers that RNA Polymerase II (Pol II)
must overcome during transcription. A high-resolution description of the barrier topography …
must overcome during transcription. A high-resolution description of the barrier topography …
[HTML][HTML] Nucleosomes are context-specific, H2A. Z-modulated barriers to RNA polymerase
Nucleosomes are barriers to transcription in vitro; however, their effects on RNA polymerase
in vivo are unknown. Here we describe a simple and general strategy to comprehensively …
in vivo are unknown. Here we describe a simple and general strategy to comprehensively …
Nucleosome positioning and kinetics near transcription-start-site barriers are controlled by interplay between active remodeling and DNA sequence
We investigate how DNA sequence, ATP-dependent chromatin remodeling and nucleosome-
depleted 'barriers' co-operate to determine the kinetics of nucleosome organization, in a …
depleted 'barriers' co-operate to determine the kinetics of nucleosome organization, in a …
[HTML][HTML] Dynamic regulation of nucleosome positioning in the human genome
The positioning of nucleosomes with respect to DNA plays an important role in regulating
transcription. However, nucleosome mapping has been performed for only limited genomic …
transcription. However, nucleosome mapping has been performed for only limited genomic …
[HTML][HTML] The kinetic landscape of nucleosome assembly: A coarse-grained molecular dynamics study
The organization of nucleosomes along the Eukaryotic genome is maintained over time
despite disruptive events such as replication. During this complex process, histones and …
despite disruptive events such as replication. During this complex process, histones and …
Structural analysis of nucleosomal barrier to transcription
DA Gaykalova, OI Kulaeva, O Volokh… - Proceedings of the …, 2015 - National Acad Sciences
Thousands of human and Drosophila genes are regulated at the level of transcript
elongation and nucleosomes are likely targets for this regulation. However, the molecular …
elongation and nucleosomes are likely targets for this regulation. However, the molecular …
Determinants of nucleosome positioning
Nucleosome positioning is critical for gene expression and most DNA-related processes.
Here we review the dominant patterns of nucleosome positioning that have been observed …
Here we review the dominant patterns of nucleosome positioning that have been observed …
[HTML][HTML] Subnucleosomal structures and nucleosome asymmetry across a genome
Genes are packaged into nucleosomal arrays, each nucleosome typically having two copies
of histones H2A, H2B, H3, and H4. Histones have distinct posttranslational modifications …
of histones H2A, H2B, H3, and H4. Histones have distinct posttranslational modifications …
In silico evidence for sequence-dependent nucleosome sliding
J Lequieu, DC Schwartz… - Proceedings of the …, 2017 - National Acad Sciences
Nucleosomes represent the basic building block of chromatin and provide an important
mechanism by which cellular processes are controlled. The locations of nucleosomes …
mechanism by which cellular processes are controlled. The locations of nucleosomes …
Nucleosome positioning by genomic excluding-energy barriers
P Milani, G Chevereau, C Vaillant… - Proceedings of the …, 2009 - National Acad Sciences
Recent genome-wide nucleosome mappings along with bioinformatics studies have
confirmed that the DNA sequence plays a more important role in the collective organization …
confirmed that the DNA sequence plays a more important role in the collective organization …