Background Rett syndrome (RTT) is a pervasive developmental disorder that is progressive
and has no effective cure. Immune dysregulation, oxidative stress, and excess glutamate in …

Aim: This study investigates the capacity of a potent anti-inflammatory nanomedicine,
celastrol, incorporated into poly (amidoamine) dendrimers, to inhibit endotoxin-mediated …

Rett syndrome is a neurodevelopmental disorder, which occurs in about 1: 15,000 females
and presents with neurologic and communication defects. It is transmitted as an X-linked …

Background Neuroinflammation mediated by microglia plays a central role in the
pathogenesis of perinatal/neonatal brain injury, including cerebral palsy (CP). Therapeutics …

Background Microglial cells have been implicated in neuroinflammation-mediated injury in
the brain, including neurodevelopmental disorders such as cerebral palsy (CP) and autism …

Cerebral palsy (CP) is a chronic childhood disorder with no effective cure.
Neuroinflammation, caused by activated microglia and astrocytes, plays a key role in the …

Poor transport of neuropharmaceutics through central nervous system (CNS) barriers limits
the development of effective treatments for CNS disorders. We present the facile synthesis of …

MECP2, an X-linked gene encoding the epigenetic factor methyl-CpG-binding protein-2, is
mutated in Rett syndrome (RTT) and aberrantly expressed in autism. Most children affected …

Mitochondrial oxidative stress is associated with many neurodegenerative diseases, such as
traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to …

Brain-related disorders have outmatched cancer and cardiovascular diseases worldwide as
the leading cause of morbidity and mortality. The lack of effective therapies and the relatively …