We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs
constructed using whole-genome sequence data from 20 studies of predominantly …

Abstract The 1000 Genomes Project and disease-specific sequencing efforts are producing
large collections of haplotypes that can be used as reference panels for genotype imputation …

Genotype imputation is a statistical technique that is often used to increase the power and
resolution of genetic association studies. Imputation methods work by using haplotype …

Genotype imputation is a key component of genetic association studies, where it increases
power, facilitates meta-analysis, and aids interpretation of signals. Genotype imputation is …

A major use of the 1000 Genomes Project (1000GP) data is genotype imputation in genome-
wide association studies (GWAS). Here we develop a method to estimate haplotypes from …

Genotype imputation is a process of estimating missing ge-notypes from the haplotype or
genotype reference panel. It can effectively boost the power of detecting single nucleotide …

Inexpensive genotyping methods are essential for genetic studies requiring large sample
sizes. In human studies, array-based microarrays and high-density haplotype reference …

Genotype imputation has become a standard tool in genome-wide association studies
because it enables researchers to inexpensively approximate whole-genome sequence …

Genotype imputation is commonly performed in genome-wide association studies because it
greatly increases the number of markers that can be tested for association with a trait. In …

The underrepresentation of non-Europeans in human genetic studies so far has limited the
diversity of individuals in genomic datasets and led to reduced medical relevance for a large …