Inflammation plays a key role in tumor promotion and development. Indeed, cyclooxygenase-
2 (COX-2) expression is strongly associated with different types of cancer. An emerging …

The beneficial effects of H2S-release and of COXs-inhibition have been exploited in the
design of novel anti-inflammatory drugs, the H2S-releasing non-steroidal anti-inflammatory …

Hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs (HS-NSAIDs) are an
emerging novel class of compounds with significant anti-inflammatory properties. They …

Hydrogen sulfide exerts a number of cytoprotective and anti-inflammatory effects in many
organ systems. In an effort to exploit these potent and beneficial effects, a number of …

A series of new hybrids of aspirin (ASA), bearing both nitric oxide (NO) and hydrogen sulfide
(H2S)-releasing moieties were synthesized and designated as NOSH compounds (1–4) …

The slow-releasing hydrogen sulfide (H2S) donor, GYY4137, caused concentration-
dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL …

Background: Melanoma is one of the most aggressive, therapy-resistant skin cancers in the
world. Hydrogen sulfide (H 2 S), a newly discovered gasotransmitter, plays a crucial role in …

For many years it has been recognized that inhibition of cyclooxygenase enzymes is
effective in reducing the incidence of many types of cancer, but the adverse effects of these …

Colorectal cancer (CRC) is the second leading cause of death due to cancer and the third
most common cancer in men and women in the USA. Nuclear factor kappa B (NF-κB) is …

Hormone-dependent estrogen receptor positive (ER+) breast cancers generally respond
well to anti-estrogen therapy. Unfortunately, hormone-independent estrogen receptor …