Some proteins with ribonuclease (RNase) activity have been shown to suppress viral
replication. A well-characterized recombinant antibody, 3D8 single-chain variable fragment …

Viral protein neutralizing antibodies have been developed but they are limited only to the
targeted virus and are often susceptible to antigenic drift. Here, we present an alternative …

The full-length NS5B protein, and the truncated NS5B proteins of classical swine fever virus
(CSFV) resulted from deletion of 24, 36, 65 or 82, amino acid residues at the C terminal were …

The structural glycoprotein E0 of classical swine fever virus (CSFV) possesses an intrinsic
RNase activity. Here we present the first comprehensive biochemical characterization of E0 …

The antiviral effect of a catalytic RNA-hydrolyzing antibody, 3D8 scFv, for intranasal
administration against avian influenza virus (H1N1) was described. The recombinant 3D8 …

The emergence of anti-influenza drug-resistant strains poses a challenge for influenza
therapy due to mutations in the virus's surface protein. Recently, there has been increasing …

Classical swine fever (CSF) is one of the major diseases causing serious economic losses
to the swine industry. To explore the feasibility of using capsid-targeted viral inactivation …

The NS3–NS5B interaction of classical swine fever virus (CSFV) is important for viral
replication. For characterisation of the interaction between the NS3 and NS5B, a series of …

Abstract Pestivirus nonstructural protein 2 (NS2) is a multifunctional, hydrophobic protein
with an important but poorly understood role in viral RNA replication and infectious virus …

Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), a
highly contagious fatal disease of swine. Few effective antiviral drugs are currently available …