GABAA receptors (GABAA-Rs) are pentameric structures consisting of two α, two β, and one
γ subunit. The α subunit influences agonist efficacy, benzodiazepine pharmacology, and …

γ-Aminobutyric acid type A (GABAA) receptor α5 subunits, which are heavily expressed in
the hippocampus, are potential drug targets for improving cognitive function. They are found …

Distinct α subunit subtypes in the molecular assembly of GABAA receptors are a critical
determinant of the functional properties of inhibitory synapses and their modulation by a …

Deletion of the β3 subunit of the GABAA receptor produces severe behavioral deficits and
epilepsy. GABAA receptor-mediated miniature inhibitory postsynaptic currents (mIPSCs) in …

The main inhibitory neurotransmitter in the mammalian brain, GABA, mediates multiple
forms of inhibitory signals, such as fast and slow inhibitory postsynaptic currents and tonic …

Extrasynaptic GABAA receptors that are tonically activated by ambient GABA are important
for controlling neuronal excitability. In hippocampal pyramidal neurons, the subunit …

GABAA receptors (GABAARs) assembled of different subunits mediate tonic and phasic
inhibition in hippocampal neurons. CA1/CA3 pyramidal cells (PCs) predominantly express …

GABAA receptors are heteropentamers that are heterogeneously distributed at different
synapses in the central nervous system. Although the modulation of GABAA receptors …

Developmental changes in miniature IPSC (mIPSC) kinetics have been demonstrated
previously in cerebellar neurons in rodents. We report that these kinetic changes in mice are …

GABAA receptors mediate fast inhibitory neurotransmission in the central nervous system
(CNS), and approximately half of these receptors contain α1 subunits. GABAA receptor α1 …