Cortical parvalbumin-expressing (Pvalb+) neurons provide robust inhibition to neighboring
pyramidal neurons, crucial for the proper functioning of cortical networks. This class of …

Parvalbumin-expressing interneurons (PVs) in the dentate gyrus provide activity-dependent
regulation of adult neurogenesis as well as maintain inhibitory control of mature neurons. In …

The generation of neurons constitutes the foundation of nervous system development, yet
the mechanisms underlying neurogenesis are not well established. The HMG-box …

Transcription factors (TFs) are responsible for the specification and fate determination of
cells as they develop from progenitor cells into specific types of cells in the brain. Sox-2 and …

Abstract Parvalbumin (PV)-expressing interneurons (PV-INs) mediate well-timed inhibition of
cortical principal neurons, and plasticity of these interneurons is involved in map remodeling …

During nervous system development, postmitotic neurons face the challenge of generating
and structurally organizing specific synapses with appropriate synaptic partners. An …

Numerous transcriptional regulators of neurogenesis have been identified in the developing
and adult brain, but how neurogenic fate is programmed at the epigenetic level remains …

PAX6 is a highly conserved transcription factor and key regulator of several neurogenic
processes, including the continuous generation of dopaminergic/GABAergic interneurons in …

Using immunohistology, electron microscopy, electrophysiology and optogenetics, we found
that proliferating adult mouse hippocampal neural precursors received immature GABAergic …

Background: Neurogenesis requires neural progenitor cell (NPC) proliferation, neuronal
migration, and differentiation. During embryonic development, neurons are generated in …