The possible role of astrocytes in the regulation of feeding has been overlooked. It is well-
established that the endothelial cells constituting the blood–brain barrier transport leptin …

To test the hypothesis that astrocytic leptin signaling induces an overall potentiation of the
neuronal response to leptin, we generated a new line of astrocyte-specific leptin receptor …

We tested the hypothesis that astrocytic activity modulates neuronal uptake and signaling of
leptin in the adult-onset obese agouti viable yellow (A vy) mouse. In the …

Background The proper establishment of hypothalamic feeding circuits during early
development has a profound influence on energy homeostasis, and perturbing this process …

Leptin, an adipocyte‐derived cytokine, crosses the blood–brain barrier to act on many
regions of the central nervous system (CNS). It participates in the regulation of energy …

Glial cells perform critical functions that alter the metabolism and activity of neurons, and
there is increasing interest in their role in appetite and energy balance. Leptin, a key …

We found that leptin receptors were expressed in hypothalamic astrocytes and that their
conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic …

To determine how astrocytic leptin signaling regulates the physiological response of mice to
diet-induced obesity (DIO), we performed metabolic analyses and hypothalamic leptin …

The agouti viable yellow (Avy) spontaneous mutation generates an unusual mouse
phenotype of agouti-colored coat and adult-onset obesity with metabolic syndrome …

It is known that various endocrine modulators, including leptin and ghrelin, have
neuroprotective roles in neurological diseases. Leptin is a hormone produced by adipocytes …