The analgesic effect of pregabalin in patients with chronic pain is reflected by changes in pharmaco‐EEG spectral indices

C Graversen, SS Olesen, AE Olesen… - British journal of …, 2012 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Pregabalin is an anticonvulsive
agent prescribed as a secondary analgesic for patients when standard pain treatment is …

Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub‐cortical mechanisms in patients with painful chronic pancreatitis

SS Olesen, C Graversen, AE Olesen… - Alimentary …, 2011 - Wiley Online Library
Aliment Pharmacol Ther 2011; 34: 878–887 Summary Background Pregabalin has a broad
spectrum of analgesic and antihyperalgesic activity in both basic and clinical studies …

Improvement in pain severity category in clinical trials of pregabalin

B Parsons, CE Argoff, A Clair, B Emir - Journal of pain research, 2016 - Taylor & Francis
Background Pregabalin is approved by the US Food and Drug Administration for the
treatment of fibromyalgia (FM), diabetic peripheral neuropathy (DPN), postherpetic neuralgia …

Does duration of neuropathic pain impact the effectiveness of pregabalin?

C Pérez, M Latymer, M Almas, M Ortiz, A Clair… - Pain …, 2017 - Wiley Online Library
Background Patients with chronic pain conditions such as neuropathic pain frequently
experience delays in diagnosis and treatment. Ideally, all patients should be treated in a …

Pregabalin and placebo responders show different effects on central pain processing in chronic pancreatitis patients

SAW Bouwense, SS Olesen, AM Drewes… - Journal of Pain …, 2015 - Taylor & Francis
Background Pain control in chronic pancreatitis is a major challenge; the mechanisms
behind analgesic treatment are poorly understood. This study aims to investigate the …

Pregabalin in the treatment of refractory neuropathic pain: results of a 15-month open-label trial

BR Stacey, RH Dworkin, K Murphy, U Sharma… - Pain …, 2008 - academic.oup.com
Objective. Neuropathic pain associated with postherpetic neuralgia (PHN) and painful
diabetic peripheral neuropathy (DPN) can be intractable and may not respond to commonly …

A pharmacokinetic comparison of pregabalin and gabapentin

D Wesche, H Bockbrader - The Journal of Pain, 2005 - jpain.org
Pregabalin is an alpha-2-delta ligand proven effective for the treatment of neuropathic pain
associated with diabetic peripheral neuropathy (DPN), postherpetic neuralgia (PHN) …

Pregabalin for chronic pain: does one medication fit all?

H Giladi, M Choiniere, MA Fitzcharles… - … medical research and …, 2015 - Taylor & Francis
Background: Pregabalin is frequently prescribed for chronic non-cancer pain. No previous
study has examined its off-label use. Objectives: Our primary aim was to assess the …

Efficacy and safety of pregabalin in treatment refractory patients with various neuropathic pain entities in clinical routine

R Freynhagen, S Grond, G Schüpfer… - … journal of clinical …, 2007 - Wiley Online Library
Aims: Conventional approaches to the management of neuropathic pain (NeP) often yield
unsatisfactory results. We aimed to investigate pregabalin, a gamma‐aminobutyric acid …

Temporal analysis of pain responders and common adverse events: when do these first appear following treatment with pregabalin

B Parsons, B Emir, A Clair - Journal of Pain Research, 2015 - Taylor & Francis
Background Pregabalin is an α2δ ligand indicated in the USA for treatment of a number of
chronic pain conditions, including diabetic peripheral neuropathy, postherpetic neuralgia …