Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is an aggressive
malignancy that invades surrounding structures and metastasizes rapidly. Although …

A hallmark of cancer, including pancreatic ductal adenocarcinoma (PDA), is a massive
stromal and inflammatory reaction. Many efforts have been made to identify the anti-or …

Background While inflammation is associated with pancreatic cancer, the underlying
mechanisms leading to cancer initiation are still being delineated. Eosinophils may promote …

Background & Aims Little is known about how the immune system affects stem cell features
of pancreatic cancer cells. Immune cells that produce interleukin 17A (IL17A) in the …

Chronic inflammation is a feature of pancreatic cancer, but little is known about how immune
cells or immune cell–related signals affect pancreatic cancer stemness and development …

Background Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with a
poor prognosis and little treatment options. The development and progression of the disease …

Background & Aims Cells of the monocyte lineage contribute to tumor angiogenesis.
Interleukin 35 (IL35) is a member of the IL12 family produced by regulatory, but not effector …

Objectives: Interleukin (IL) 22 is a recently identified T-cell-derived cytokine. IL-22 binds at
the cell surface to a heterodimer receptor complex composed of IL-22 receptor (R) 1 and IL …

Purpose Type 3 innate lymphocytes (ILC3s) are reported to be involved in lung cancer,
possibly by producing interleukin-22 (IL-22). However, whether ILC3s and their secreted IL …

Background and aims Interleukin-13 (IL-13) is an anti-inflammatory cytokine produced in
cells of hematopoetic origin. It is not known whether pancreatic cancer cells produce IL-13 or …