Mild high-renin essential hypertension: neurogenic human hypertension?

M Esler, S Julius, A Zweifler, O Randall… - … England Journal of …, 1977 - Mass Medical Soc
To determine whether the elevated plasma renin activity in some cases of mild essential
hypertension expresses sympathetic-nervous-system overactivity, we compared indexes of …

Renin and sympathetic nervous system responsiveness to adrenergic stimuli in essential hypertension

MD Esler, PJ Nestel - The American Journal of Cardiology, 1973 - Elsevier
The possibility was explored that in hypertension, sympathetic nervous activity and renin-
angiotensin status may be linked, especially in those subgroups of hypertensive patients …

Suppression of sympathetic nervous function in low-renin essential hypertension

M Esler, O Randall, J Bennett, A Zweifler, S Julius… - The Lancet, 1976 - Elsevier
Study of general hæmodynamics in 15 patients with low-renin essential hypertension
showed hæmodynamic and pathophysiological heterogeneity. However, there was …

Relation of renin status to neurogenic vascular resistance in borderline hypertension

MD Esler, S Julius, OS Randall, CN Ellis… - The American Journal of …, 1975 - Elsevier
The relation of renin-angiotensin status to general hemodynamics and to neurogenic
vascular resistance was studied in patients with borderline hypertension. Plasma renin …

Suppressed plasma renin activity in essential hypertension: roles of plasma volume, blood pressure, and sympathetic nervous system

A JOSE, JR CROUT, NM Kaplan - Annals of internal medicine, 1970 - acpjournals.org
Possible mechanisms causing suppressed plasma renin activity (PRA) in about 25% of
patients with essential hypertension are examined. Seven patients with normally responsive …

Renin as a risk factor in essential hypertension: more evidence

HR Brunner, JE Sealey, JH Laragh - The American journal of medicine, 1973 - Elsevier
When patients with essential hypertension are classified into three major subgroups
according to their plasma renin levels, they appear to exhibit different physiologic and …

Role of the autonomic nervous system in mild human hypertension.

S Julius, MD Esler, OS Randall - Clinical Science and Molecular …, 1975 - europepmc.org
1. Some of the haemodynamic abnormalities in mild (borderline) human hypertension
appear to be neurogenic, since they can be completely abolished by pharmacological …

Relation of age, diastolic pressure and known duration of hypertension to presence of low renin essential hypertension

ML Tuck, GH Williams, JP Cain, JM Sullivan… - The American Journal of …, 1973 - Elsevier
Plasma renin activity and aldosterone secretion rates were measured in 100 patients with
essential hypertension in response to a low sodium diet and upright posture. Plasma renin …

Reciprocal relation between renin dependency and sodium dependency in essential hypertension

H Gavras, AB Ribeiro, I Gavras… - New England Journal of …, 1976 - Mass Medical Soc
To investigate the roles of angiotensin II and sodium in essential high-renin, normal-renin
and low-renin hypertension, 14 patients received the competitive antagonist of angiotensin …

Possible role of renin in hypertension as suggested by renin-sodium profiling and inhibition of converting enzyme

DB Case, JM Wallace, HJ Keim… - … England Journal of …, 1977 - Mass Medical Soc
To block renin activity, a nonapeptide converting-enzyme inhibitor was given to 65 seated
hypertensive patients. Depressor responses occurred only when control plasma renin …