Schistosoma mansoni: N-acetylcysteine downregulates oxidative stress and enhances the
antischistosomal activity of artemether in mice. - Abstract - Europe PMC Sign in | Create an …

Artemether (Art), a derivative of the antimalarial artemisinin, also exhibit antischistosomal
properties. N-acetylcysteine (NAC) has a diversity of applications, largely because of the …

Glutathione S-transferase (GST) and superoxide dismutase (SOD) are major antioxidant
enzymes of schistosomes that are involved in detoxification processes. To study the effect of …

Among the potential alternatives to praziquantel, interestingly, the antimalarial artemether
(Art) also exhibits antischistosomal properties. Previous in vitro studies suggested that Art …

Objective To investigate the possible effect of artesunate (ART) on schistosome thioredoxin
glutathione reductase (TGR) and cytochrome c peroxidase (CcP) in Schistosoma mansoni …

The main pathology associated with Schistosomiasis mansoni is granulomatous
inflammation that may develop into hepatosplenic disease with fibrosis and …

Objective To observe the effect of reduced glutathione (GSH) and glutathione depleting
agent 1-chloro-2, 4-dinitrobenzene (CDNB) on the susceptibility of adult Schistosoma …

Background Treatment of schistosomiasis has relied on the anthelmintic drug praziquantel
(PZQ) for more than a generation. Despite its celebrated performance for treatment and …

Background Artemisinin (ART) analogs, such as dihydroartemisinin, arteether, artemether,
and artesunate, all featuring an endoperoxide bridge, have demonstrated efficacy against …

OBJECTIVE: To investigate immune mechanisms possibly involved in the amelioration of
histopathological changes in livers of Schistosoma mansoni-infected mice treated with …