Human population studies with the exfoliated buccal micronucleus assay: statistical and epidemiological issues

M Ceppi, B Biasotti, M Fenech, S Bonassi - Mutation Research/Reviews in …, 2010 - Elsevier
OBJECTIVES: Micronucleus (MN) assay in buccal exfoliated cells is a minimally invasive
method for monitoring genetic damage in human populations. Statistical and …

The HUman MicroNucleus project on eXfoLiated buccal cells (HUMNXL): The role of life-style, host factors, occupational exposures, health status, and assay protocol

S Bonassi, E Coskun, M Ceppi, C Lando… - … Research/Reviews in …, 2011 - Elsevier
The human buccal micronucleus cytome assay (BMCyt) is one of the most widely used
techniques to measure genetic damage in human population studies. Reducing protocol …

State of the art survey of the buccal micronucleus assay—a first stage in the HUMNXL project initiative

S Bonassi, B Biasotti, M Kirsch-Volders… - …, 2009 - academic.oup.com
The study of DNA damage in exfoliated buccal cells is a minimally invasive method for
monitoring populations for exposure to genotoxic agents. The presence of micronuclei (MN) …

Clinical application of micronucleus test in exfoliated buccal cells: A systematic review and metanalysis

C Bolognesi, S Bonassi, S Knasmueller… - … research/reviews in …, 2015 - Elsevier
The micronucleus assay in uncultured exfoliated buccal mucosa cells, involving minimally
invasive sampling, was successfully applied to evaluate inhalation and local exposure to …

The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps

N Holland, C Bolognesi, M Kirsch-Volders… - … Research/Reviews in …, 2008 - Elsevier
The micronucleus (MN) assay in exfoliated buccal cells is a useful and minimally invasive
method for monitoring genetic damage in humans. This overview has concluded that …

Harmonisation of the micronucleus assay in human buccal cells—a Human Micronucleus (HUMN) project () initiative commencing in 2007

M Fenech, C Bolognesi, M Kirsch-Volders… - …, 2007 - academic.oup.com
The buccal cell micronucleus (MN) assay, first proposed by Stich et al.(1, 2), is useful as a
biomarker of genetic damage caused by life-style habits (eg consumption of tobacco …

Buccal micronucleus cytome assay: results of an intra-and inter-laboratory scoring comparison

C Bolognesi, P Roggieri, M Ropolo, P Thomas… - …, 2015 - academic.oup.com
The buccal micronucleus cytome (BMCyt) assay is a minimally invasive approach for
measuring DNA damage, cell proliferation, cell differentiation and cell death in exfoliated …

The HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells—past, present and future

M Fenech, N Holland, E Zeiger, WP Chang… - …, 2011 - academic.oup.com
Abstract The International Human Micronucleus (HUMN) Project (www. humn. org) was
founded in 1997 to coordinate worldwide research efforts aimed at using micronucleus (MN) …

Potential uses, limitations, and basic procedures of micronuclei and nuclear abnormalities in buccal cells

O Torres-Bugarín, MG Zavala-Cerna, A Nava… - Disease …, 2014 - Wiley Online Library
The use of biomarkers as tools to evaluate genotoxicity is increasing recently. Methods that
have been used previously to evaluate genomic instability are frequently expensive …

Buccal micronucleus cytome assay

P Thomas, N Holland, C Bolognesi, M Kirsch-Volders… - Nature protocols, 2009 - nature.com
Abstract The Buccal Micronucleus Cytome (BMCyt) assay is a minimally invasive method for
studying DNA damage, chromosomal instability, cell death and the regenerative potential of …