Podocin mutations (NPHS2 gene) are responsible for the autosomal recessive form of
steroid-resistant nephrotic syndrome. As a result of a screening for these gene alterations in …

Mutations in the gene encoding podocin (NPHS2) cause autosomal recessive steroid-
resistant nephrotic syndrome (SRNS). For addressing the possibility of a genotype …

Mutations in NPHS2, the gene that encodes podocin, are well-established causes of both
familial and sporadic steroid-resistant focal segmental glomerulosclerosis (FSGS) in the …

Mutations in NPHS2, encoding podocin, have been identified in childhood onset focal and
segmental glomerulosclerosis (FSGS). The role of NPHS2 in adult disease is less well …

Recessive NPHS2 (podocin) mutations account for up to approximately 30% of steroid-
resistant idiopathic FSGS in children and are associated with a reduced risk for disease …

BACKGROUND:: Posttransplant recurrence of focal segmental glomerulosclerosis (FSGS)
occurs in a relevant proportion of FSGS patients and represents an important clinical …

Steroid-resistant nephrotic syndrome (SRNS) represents a heterogeneous group of kidney
disorders that are often resistant to other immunosuppressive agents and tend to progress to …

Mutations of NPHS2, encoding podocin, are the main cause of autosomal recessive steroid-
resistant nephrotic syndrome (NS) presenting in childhood. Adult-onset steroid-resistant NS …

A total of 179 children with sporadic nephrotic syndrome were screened for podocin
mutations: 120 with steroid resistance, and 59 with steroid dependence/frequent relapses …

Background Focal and segmental glomerulosclerosis (FSGS) is the most common histologic
pattern of renal injury seen in adults with idiopathic proteinuria. Homozygous or compound …