An important aspect of brain cholinesterase function is related to enzymatic differences. The
brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) …

The brain of mammals contains two major forms of cholinesterases (ChEs):
acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The two forms differ …

The most important therapeutic effect of cholinesterase inhibitors (ChEI) on approximately
50% of Alzheimer's disease (AD) patients is to stabilize cognitive function at a steady level …

Butyrylcholinesterase is a serine hydrolase biochemically related to the cholinergic enzyme
acetylcholinesterase. It is capable of hydrolyzing esters of choline. Butyrylcholinesterase has …

The cholinergic hypothesis of decline in dementia, whereby deficits in learning, memory and
behavior are caused, at least in part, by decreased levels of acetylcholine (ACh) in the brain …

Current approaches to the treatment of cognitive and behavioral symptoms of Alzheimer
disease emphasize the use of cholinesterase inhibitors. The kinetic effects of the …

Acetylcholinesterase (AChE) predominates in the healthy brain, with butyrylcholinesterase
(BuChE) considered to play a minor role in regulating brain acetylcholine (ACh) levels …

Background. Cholinesterases are a group of serine hydrolases that split the neurotransmitter
acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and …

We have described recently an acetylcholinesterase (AChE) knockout mouse. While
comparing the tissue distribution of AChE and butyrylcholinesterase (BChE), we found that …

Background: Butyrylcholinesterase (BChE), also known as the “pseudo” or “non-neuronal”
cholinesterase, is traditionally thought to have a restricted CNS distribution and to play little …