Purpose: Connexins and aquaporins play essential roles in maintaining lens homeostasis
and transparency and there is a close physical and functional relationship between these …

Both connexin 50 (Cx50) and aquaporin 0 (AQP0) have important roles in lens development
and homeostasis, and their mutations are associated with human congenital cataracts. We …

Lens, an avascular tissue involved in light transmission, generates an internal
microcirculatory system to promote ion and fluid circulation, thus providing nutrients to …

Purpose: We reported previously that aquaporin 0 (AQP0) modulates lens fiber cell gap
junction (GJ) channel function. The present study was conducted to find out whether the C …

Purpose.: Lens fiber cell membranes contain aquaporin-0 (AQP0), which constitutes
approximately 50% of the total fiber cell membrane proteins and has a dual function as a …

Purpose: The objective of this study was to understand the molecular and physiologic
mechanisms behind the lens cataract differences in Aquaporin 0-knockout-Heterozygous …

Maintenance of proper biomechanics of the eye lens is important for its structural integrity
and for the process of accommodation to focus near and far objects. Several studies have …

Purpose: The roles of gap junction protein connexin 50 (Cx50) encoded by Gja8, during lens
development are not fully understood. Connexin 50 knockout (KO) lenses have decreased …

Connexins play essential roles in lens homeostasis and development. Here, we identified a
new role for Cx50 that mediates cell-cell adhesion function. Cx50 enhanced the adhesive …

Aquaporin 0 (AQP0) is the most abundant lens membrane protein, and loss of function in
human and animal models leads to cataract formation. AQP0 has several functions in the …