Codon identity regulates mRNA stability and translation efficiency during the maternal‐to‐zygotic transition
Cellular transitions require dramatic changes in gene expression that are supported by
regulated mRNA decay and new transcription. The maternal‐to‐zygotic transition is a …
regulated mRNA decay and new transcription. The maternal‐to‐zygotic transition is a …
[HTML][HTML] Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability
Background The regulation of messenger RNA (mRNA) stability has a profound impact on
gene expression dynamics during embryogenesis. For example, in animals, maternally …
gene expression dynamics during embryogenesis. For example, in animals, maternally …
[HTML][HTML] Codon usage and 3′ UTR length determine maternal mRNA stability in zebrafish
The control of mRNA stability plays a central role in regulating gene expression. In
metazoans, the earliest stages of development are driven by maternally supplied mRNAs …
metazoans, the earliest stages of development are driven by maternally supplied mRNAs …
[HTML][HTML] Codon and amino acid content are associated with mRNA stability in mammalian cells
Messenger RNA (mRNA) degradation plays a critical role in regulating transcript levels in
the cell and is a major control point for modulating gene expression. In yeast and other …
the cell and is a major control point for modulating gene expression. In yeast and other …
[HTML][HTML] Translation and mRNA stability control
Q Wu, AA Bazzini - Annual review of biochemistry, 2023 - annualreviews.org
Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the
post-transcriptional process that profoundly impact protein production in a cell. While it is …
post-transcriptional process that profoundly impact protein production in a cell. While it is …
[HTML][HTML] Codon optimality is a major determinant of mRNA stability
Summary mRNA degradation represents a critical regulated step in gene expression.
Although the major pathways in turnover have been identified, accounting for disparate half …
Although the major pathways in turnover have been identified, accounting for disparate half …
[HTML][HTML] Translation affects mRNA stability in a codon-dependent manner in human cells
mRNA translation decodes nucleotide into amino acid sequences. However, translation has
also been shown to affect mRNA stability depending on codon composition in model …
also been shown to affect mRNA stability depending on codon composition in model …
[HTML][HTML] Attenuated codon optimality contributes to neural-specific mRNA decay in Drosophila
Tissue-specific mRNA stability is important for cell fate and physiology, but the mechanisms
involved are not fully understood. We found that zygotic mRNA stability in Drosophila …
involved are not fully understood. We found that zygotic mRNA stability in Drosophila …
Determinants of translational fidelity and efficiency in vertebrate mRNAs
M Kozak - Biochimie, 1994 - Elsevier
Determinants of translational fidelity and efficiency in vertebrate mRNAs Page 1 Biochimie (1994)
76, 815-82 l © Soc:i6t6 fran~aise de biochimie et biologic mol6culaire / Elsevier, Paris 815 …
76, 815-82 l © Soc:i6t6 fran~aise de biochimie et biologic mol6culaire / Elsevier, Paris 815 …
Messenger RNA decay during aging and development
G Brewer - Ageing research reviews, 2002 - Elsevier
Gene expression is a combination of many processes, including transcription, pre-mRNA
processing, nucleocytoplasmic transport of mRNA, translation, mRNA decay, and protein …
processing, nucleocytoplasmic transport of mRNA, translation, mRNA decay, and protein …
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