Vaccine-induced mucosal immunity to poliovirus: analysis of cohorts from an open-label, randomised controlled trial in Latin American infants
PF Wright, RI Connor, WF Wieland-Alter… - The Lancet infectious …, 2016 - thelancet.com
Background Identification of mechanisms that limit poliovirus replication is crucial for
informing decisions aimed at global polio eradication. Studies of mucosal immunity induced …
informing decisions aimed at global polio eradication. Studies of mucosal immunity induced …
Intestinal immune responses to type 2 oral polio vaccine (OPV) challenge in infants previously immunized with bivalent OPV and either high-dose or standard …
EB Brickley, CB Strauch… - The Journal of …, 2018 - academic.oup.com
Background The impact of inactivated polio vaccines (IPVs) on intestinal mucosal immune
responses to live poliovirus is poorly understood. Methods In a 2014 phase 2 clinical trial …
responses to live poliovirus is poorly understood. Methods In a 2014 phase 2 clinical trial …
Intestinal immunity to poliovirus following sequential trivalent inactivated polio vaccine/bivalent oral polio vaccine and trivalent inactivated polio vaccine–only …
EB Brickley, W Wieland-Alter, RI Connor… - Clinical Infectious …, 2018 - academic.oup.com
Background Identifying polio vaccine regimens that can elicit robust intestinal mucosal
immunity and interrupt viral transmission is a key priority of the polio endgame. Methods In a …
immunity and interrupt viral transmission is a key priority of the polio endgame. Methods In a …
Humoral and intestinal immunity induced by new schedules of bivalent oral poliovirus vaccine and one or two doses of inactivated poliovirus vaccine in Latin …
Background Replacement of the trivalent oral poliovirus vaccine (tOPV) with bivalent types 1
and 3 oral poliovirus vaccine (bOPV) and global introduction of inactivated poliovirus …
and 3 oral poliovirus vaccine (bOPV) and global introduction of inactivated poliovirus …
Impact of inactivated poliovirus vaccine on mucosal immunity: implications for the polio eradication endgame
EPK Parker, NA Molodecky, M Pons-Salort… - Expert review of …, 2015 - Taylor & Francis
The polio eradication endgame aims to bring transmission of all polioviruses to a halt. To
achieve this aim, it is essential to block viral replication in individuals via induction of a …
achieve this aim, it is essential to block viral replication in individuals via induction of a …
Systematic review of mucosal immunity induced by oral and inactivated poliovirus vaccines against virus shedding following oral poliovirus challenge
TR Hird, NC Grassly - PLoS pathogens, 2012 - journals.plos.org
Inactivated poliovirus vaccine (IPV) may be used in mass vaccination campaigns during the
final stages of polio eradication. It is also likely to be adopted by many countries following …
final stages of polio eradication. It is also likely to be adopted by many countries following …
The duration of intestinal immunity after an inactivated poliovirus vaccine booster dose in children immunized with oral vaccine: a randomized controlled trial
Background In 2014, 2 studies showed that inactivated poliovirus vaccine (IPV) boosts
intestinal immunity in children previously immunized with oral poliovirus vaccine (OPV). As a …
intestinal immunity in children previously immunized with oral poliovirus vaccine (OPV). As a …
[HTML][HTML] Exploring the relationship between polio type 2 serum neutralizing antibodies and intestinal immunity using data from two randomized controlled trials of new …
Background Inactivated polio vaccine (IPV) is now the only source of routine type 2
protection. The relationship, if any, between vaccine-induced type 2 humoral and intestinal …
protection. The relationship, if any, between vaccine-induced type 2 humoral and intestinal …
Vaccine schedules and the effect on humoral and intestinal immunity against poliovirus: a systematic review and network meta-analysis
GR Macklin, NC Grassly, RW Sutter, O Mach… - The Lancet Infectious …, 2019 - thelancet.com
Background The eradication of wild and vaccine-derived poliovirus requires the global
withdrawal of oral poliovirus vaccines (OPVs) and replacement with inactivated poliovirus …
withdrawal of oral poliovirus vaccines (OPVs) and replacement with inactivated poliovirus …
Effect of a single inactivated poliovirus vaccine dose on intestinal immunity against poliovirus in children previously given oral vaccine: an open-label, randomised …
Background Intestinal immunity induced by oral poliovirus vaccine (OPV) is imperfect and
wanes with time, permitting transmission of infection by immunised children. Inactivated …
wanes with time, permitting transmission of infection by immunised children. Inactivated …
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