To date, more than a dozen studies have investigated the role of HLA genes in determining
clinical course and disease severity in multiple sclerosis (MS); in each of these studies …

An association between multiple sclerosis (MS) and the human leukocyte antigen (HLA)
complex, a dense cluster of genes on the short arm of chromosome 6, was first noted over …

Background: Multiple sclerosis (MS) in the pediatric age group is being increasingly
recognized. In adults, complex interactions between genetic and environmental factors …

Variation in major histocompatibility complex genes on chromosome 6p21. 3, specifically the
human leukocyte antigen HLA-DR2 or DRB1* 1501-DQB1* 0602 extended haplotype …

Background: The association between multiple sclerosis and class II alleles of the major
histocompatibiliy complex, in particular the DRB1* 1501-DQB1* 0602 haplotype, is well …

Models of disease susceptibility in multiple sclerosis (MS) often assume a dominant action
for the HLA-DRB1* 1501 allele and its associated haplotype (DRB1* 1501-DQB1* 0602 or …

The human leucocyte antigen (HLA) class II haplotype DRB1* 15–DQB1* 06 (DR15–DQ6) is
associated with susceptibility to multiple sclerosis (MS), and HLA class I associations in MS …

Objective: To investigate the HLA-DR associations in relapsing-remitting/secondary
progressive multiple sclerosis (RR/SPMS) and primary progressive MS (PPMS). The HLA …

Objective Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is
known to influence susceptibility to multiple sclerosis with the strongest effect originating …

The importance of the HLA-DR locus to multiple sclerosis (MS) susceptibility was assessed
in 542 sib pairs with MS and in their families. By genotyping 1,978 individuals for HLA-DRB1 …