Background—There are conflicting data regarding the efficacy of cardiac resynchronization
therapy (CRT) in patients with heart failure (HF) and without left bundle branch block …

Background: Mild heart failure (HF) patients without left bundle branch block (LBBB) did not
derive a significant reduction in risk of a HF event/death in the MADIT-CRT trial (Multicenter …

Importance The benefits of cardiac resynchronization therapy (CRT) in clinical trials were
greater among patients with left bundle-branch block (LBBB) or longer QRS duration …

Background Previous studies have shown conflicting results regarding the benefit of cardiac
resynchronization therapy (CRT) by sex and QRS duration. Methods and Results In the …

Background—The impact of QRS morphology and duration on the effectiveness of cardiac
resynchronization therapy (CRT) has been usually assessed separately. The interaction …

Cardiac resynchronization therapy (CRT) is effective for the treatment of patients with heart
failure and a wide QRS duration, particularly left bundle branch block. However, subjects …

Background The Multicenter Automatic Defibrillator Implantation Trial with Cardiac
Resynchronization Therapy (MADIT-CRT) showed that early intervention with cardiac …

Aims The prognostic implications of QRS duration and morphology in heart failure patients
treated with cardiac resynchronization therapy (CRT) remains debated. The present …

Aims Recent guidelines recommend cardiac resynchronization therapy (CRT) in mildly
symptomatic heart failure (HF) but favour left bundle branch block (LBBB) morphology in …

Background: Benefit from cardiac resynchronization therapy (CRT) varies by QRS
characteristics; individual randomized trials are underpowered to assess benefit for …