Casein kinases regulate a wide range of cellular functions in eukaryotes, including
phosphorylation of proteins that are substrates for degradation via the ubiquitin-proteasome …

ABSTRACT The casein kinase 2 (CK2) complex has garnered extensive attention over the
past decades as a potential therapeutic target for diverse human diseases, including cancer …

Eukaryotic cells utilize complex signaling systems to detect their environments, responding
and adapting as new conditions arise during evolution. The basidiomycete fungus …

Cryptococcus neoformans is a fungal pathogen of immunocompromised people that causes
fatal meningitis. The fungal cell wall is essential to viability and pathogenesis of C …

Cryptococcus neoformans is the leading cause of fungal meningitis in immunocomprised
populations. Although extensive studies have been conducted on signal transduction …

Cell wall biogenesis and integrity are crucial for fungal growth, pathogenesis and survival,
and are attractive targets for antifungal therapy. In this study, we identify, delete and analyse …

The stress-activated p38/Hog1 mitogen-activated protein kinase (MAPK) pathway is
structurally conserved in many diverse organisms, including fungi and mammals, and …

Cell wall integrity is crucial for fungal growth, survival, and pathogenesis. Responses to
environmental stresses are mediated by the highly conserved Pkc1 protein and its …

A defect in the PKA1 gene encoding the catalytic subunit of cyclic adenosine 5′-
monophosphate (cAMP)–dependent protein kinase A (PKA) is known to reduce capsule size …

The polysaccharide capsule is one of the established virulence factors in Cryptococcus
neoformans that provides a barrier against the host-mediated immune response. Mutation of …