Tissue engineering scaffolds play critical roles in skeletal tissue regeneration by supporting
physiological loads as well as enhancing cell/tissue migration and formation. These roles …

Tissue engineering utilizes porous biomaterial scaffolds to deliver biological factors that
accelerate tissue healing. These two functions require scaffolds be designed for mechanical …

An often-proposed tissue engineering design hypothesis is that the scaffold should provide
a biomimetic mechanical environment for initial function and appropriate remodeling of …

A tissue engineering scaffold provides a proper environment to support physiological loads,
and enhance cell migration and delivery for re-modeling of regenerating tissue. Hence, in …

Bone tissue engineering scaffolds must shape regenerating tissue, provide temporary
mechanical support and enhance tissue regeneration. These requirements result in …

Abstract Design of tissue scaffolds in terms of multiple objectives such as mechanical and
biological performances simultaneously remains challenging. In this paper, we present the …

Scaffold-based bone tissue engineering has been extensively developed as a potential
means to treatment of large bone defects. To enhance the biomechanical performance of …

Tissue scaffolds are typically designed and fabricated to match native bone properties.
However, it is unclear if this would lead to the best tissue ingrowth outcome within the …

A promising new treatment for large and complex bone defects is to implant specifically
designed and additively manufactured synthetic bone scaffolds. Optimizing the scaffold …

In bone tissue engineering, the scaffold has not only to allow the diffusion of cells, nutrients
and oxygen but also provide adequate mechanical support. One way to ensure the scaffold …