The presence of pairs of basic amino acids within the sequence of orphanin FQ/nociceptin
(OFQ/N) peptide, the endogenous ligand for the ORL1KOR-3 receptor, has raised the …

The presence of pairs of basic amino acids within the orphanin FQ/Nociceptin (OFQ/N)
sequence has raised the possibility that truncated versions of the peptide might be …

Orphanin FQ/nociceptin (OFQ/N) is generated from a larger precursor peptide, prepro-
orphanin FQ (ppOFQ). Within the sequence of murine ppOFQ is another putative …

The cloning of a fourth member of the opioid receptor family has led to the discovery of a
new neuropeptide termed orphanin FQ or nociceptin (OFQ/N). Studies in CD-1 mice confirm …

Orphanin FQ/nociceptin (OFQ/N), the endogenous ligand for the ORL-1/KOR-3 receptor,
produces a wide variety of behavioral responses. Its precursor protein, prepro-OFQ/N …

Previous work reveals that orphanin FQ/nociceptin (OFQ/N) administered supraspinally
produces an initial hyperalgesic response followed by analgesia. Spinally, OFQ/N elicits a …

The heptadecapeptide orphanin FQ or nociceptin (OFQ/N), the endogenous ligand for the
orphan opioid receptor, has a complex pharmacology in mice, eliciting either an anti …

Orphanin FQ/Nociceptin (OFQ/N) administered peripherally was an effective analgesic in the
tailflick test in mice (ED5016. 3 μg) It had a peak effect at 5 min and lasted up to 30 min. The …

Orphanin FQ/nociceptin (OFQ/N) is a recently identified neuropeptide with high affinity for
the orphan opioid receptor. OFQ/N blocked morphine analgesia in mice in a dose …

Orphanin FQ/nociceptin (OFQ/N), the endogenous ligand for the “orphan” opioid receptor
ORL-1 (NOP1) was first identified in 1995. In the years since its discovery, a large body of …