Context: substantial evidence suggests that the expression of steroid metabolizing enzymes
in endometriosis is altered, turning the ectopic endometrium into a source of 17β-estradiol …

Aberrant aromatase expression in stromal cells of endometriosis gives rise to conversion of
circulating androstenedione to estrone in this tissue, whereas aromatase expression is …

BACKGROUND Estradiol (E 2) is an important promoter of the growth of both eutopic and
ectopic endometrium. The findings with regard to the expression and activity of …

Context: Endometriosis affects 10% of the women before menopause and has important
personal, professional, and societal economic burdens. Because current medical treatments …

In the human endometrium, inactivation of 17β-estradiol to estrone is catalyzed by 17β-
hydroxysteroid dehydrogenase type 2 (17βHSD2). Previous studies have shown that the …

Conversion of C19 steroids to estrogens is catalyzed by aromatase in human ovary,
placenta and extraglandular tissues such as adipose tissue, skin and the brain. Aromatase …

In contrast to normal endometrium, the expression of aromatase is aberrant in endometriosis
and is stimulated by prostaglandin E 2 (PGE 2). This results in local production of estrogen …

Estrogen is the most important known factor that stimulates the growth of endometriosis.
Estrogen delivery to endometriotic implants was classically viewed to be only via the …

Aromatase activity is absent in normal endometrium. In contrast, aromatase is expressed
aberrantly in endometriosis, which gives rise to strikingly high levels of aromatase activity in …

Cytosol and nuclear estrogen receptors were detected in 73% and 89% of untreated
endometriosis specimens, respectively. The corresponding figures for cytosol and nuclear …