Time for primary review: 15 days Aims Chaperone-mediated autophagy (CMA) is a selective
mechanism for the degradation of soluble cytosolic proteins bearing the sequence KFERQ …

Background: Alterations in autophagy have been reported in hypertrophic cardiomyopathy
(HCM) caused by Danon disease, Vici syndrome, or LEOPARD syndrome, but not in HCM …

Dear Editor, Accumulating studies have demonstrated that the autophagy–lysosome
pathway, a major pathway governing protein and organelle degradation and recycling, is a …

Cardiomyocytes are terminally differentiated cells and thus do not have the ability to dilute
damaged proteins and organelles by cell division. Thus, proteolytic and recycling systems …

Autophagy is a critical biological process in which cytoplasmic components are sequestered
in autophagosomes and degraded in lysosomes. This highly conserved pathway controls …

Basal autophagy is tightly regulated by transcriptional and epigenetic factors to maintain
cellular homeostasis. Dysregulation of cardiac autophagy is associated with heart diseases …

Senescence-associated autophagy downregulation leads to cardiomyocyte dysfunction.
Coactivator-associated arginine methyltransferase 1 (CARM1) participates in many cellular …

Chaperone-mediated autophagy (CMA) is a chaperone-dependent process of selective
cytosolic protein turnover that targets specific proteins to lysosomes for degradation …

Despite progress in cardiovascular research and evidence-based therapies, heart failure is
a leading cause of morbidity and mortality in industrialized countries. Cardiac remodeling is …

Recent work has demonstrated that autophagy, a phylogenetically conserved, lysosome-
mediated pathway of protein degradation, is a key participant in pathological cardiac …