Most human neurodegenerative diseases have a number of common features, including
adult onset, progressive degeneration of selected neuronal populations and formation of …

▪ Abstract A number of approaches have been taken to recreate and to study the role of
genes associated with human neurodegenerative diseases in the model organism …

In Alzheimer's disease and related disorders, the microtubule-associated protein Tau is
abnormally hyperphosphorylated and aggregated into neurofibrillary tangles. Mutations in …

Neurodegenerative diseases encompass a large group of neurological disorders. Clinical
symptoms can include memory loss, cognitive impairment, loss of movement or loss of …

Abstract Spinocerebellar Ataxia type 1 (SCA1) and Huntington's disease (HD) are two
polyglutamine disorders caused by expansion of a CAG repeat within the coding regions of …

Polyglutamine (polyQ) diseases, resulting from a dynamic expansion of glutamine repeats in
a polypeptide, are a class of genetically inherited late onset neurodegenerative disorders …

Huntington's disease (HD) is caused by an extended polyglutamine (polyQ) tract in the
Huntingtin protein. Neuronal and glial dysfunction precedes the neurodegeneration and …

Sequestration of the transcriptional coactivator CREB-binding protein (CBP), a histone
acetyltransferase, has been implicated in the pathogenesis of polyglutamine expansion …

Recent studies indicate that the visual system appears more frequently affected in
polyglutamine diseases than expected previously. Here, we investigated retinal …

Neurodegenerative diseases are progressive disorders of the nervous system that affect
specific cellular populations in the central and peripheral nervous systems. Although most …