Metabolomics analysis reveals heavy metal copper-induced cytotoxicity in HT-29 human colon cancer cells

Y Xiao, Q Zhai, G Wang, X Liu, J Zhao, F Tian… - RSC …, 2016 - pubs.rsc.org
Copper (Cu) is toxic to humans and animals as a result of the generation of reactive oxygen
species (ROS) through Fenton reactions and abnormal alterations in metabolism and …

Toxicity, gut microbiota and metabolome effects after copper exposure during early life in SD rats

J Dai, X Yang, Y Yuan, Y Jia, G Liu, N Lin, H Xiao… - Toxicology, 2020 - Elsevier
Copper, an essential microelement, can still be harmful to health and has a significant
impact on the gut microbiota, which is closely related to health when copper is ingested …

Metabolomics analysis reveals the effects of copper on mitochondria-mediated apoptosis in kidney of broiler chicken (Gallus gallus)

J Liao, F Yang, Y Bai, W Yu, N Qiao, Q Han… - Journal of Inorganic …, 2021 - Elsevier
Copper (Cu) is one of the ubiquitous environmental pollutants which have raised wide
concerns about the potential toxic effects and public health threat. For deeply investigating …

Lipidomics reveals insights on the biological effects of copper oxide nanoparticles in a human colon carcinoma cell line

NGC Soria, DS Aga, GE Atilla-Gokcumen - Molecular Omics, 2019 - pubs.rsc.org
Engineered nanomaterials have unique properties compared to their bulk counterparts.
Copper oxide nanoparticles (CuO NPs) are one example of nanomaterials used in a wide …

Proteomics revealed the crosstalk between copper stress and cuproptosis, and explored the feasibility of curcumin as anticancer copper ionophore

Y Yang, S Liang, H Geng, M Xiong, M Li, Q Su… - Free Radical Biology …, 2022 - Elsevier
As an essential micronutrient element in organisms, copper controls a host of fundamental
cellular functions. Recently, copper-dependent cell growth and proliferation have been …

A metabolomics investigation of the metabolic changes of raji b lymphoma cells undergoing apoptosis induced by zinc ions

N Yoon, H Lee, G Lee, EH Kim, SH Kim, JO Lee… - Metabolites, 2021 - mdpi.com
Zinc plays a pivotal role in the function of cells and can induce apoptosis in various cancer
cells, including Raji B lymphoma. However, the metabolic mechanism of Zn-induced …

Metabolomics: a promising tool for deciphering metabolic impairment in heavy metal toxicities

MSH Akash, A Yaqoob, K Rehman, M Imran… - Frontiers in Molecular …, 2023 - frontiersin.org
Heavy metals are the metal compounds found in earth's crust and have densities higher
than that of water. Common heavy metals include the lead, arsenic, mercury, cadmium …

Heavy metal exposure and metabolomics analysis: an emerging frontier in environmental health

K Ilyas, H Iqbal, MSH Akash, K Rehman… - … Science and Pollution …, 2024 - Springer
Exposure to heavy metals in various populations can lead to extensive damage to different
organs, as these metals infiltrate and bioaccumulate in the human body, causing metabolic …

Functional genomics and metabolomics reveal the toxicological effects of cadmium in Mus musculus mice

MA García-Sevillano, N Abril, R Fernández-Cisnal… - Metabolomics, 2015 - Springer
Cadmium (Cd) is an environmental pollutant that accumulates in the organisms causing
serious health problems. Over the past decades, omics studies have been conducted trying …

Proteomic analysis of the copper ion-induced stress response in a human embryonic carcinoma cell line

DMR Han, MR Choi, KH Jung, HT Lee… - International …, 2012 - journals.sagepub.com
Excessive exposure to copper, a redox-active metal, generates free radicals, which can
cause cellular damage. In this study, we aim to identify the proteins that are up-or …