Hypertension is a multifactorial disease involving complex interactions between genetic and
environmental factors. Development of experimental models of hypertension allowed …

Elevated blood pressure (BP), or hypertension, is the main risk factor for cardiovascular
disease. As a multifactorial and systemic disease that involves multiple organs and systems …

Hypertension is one of the leading causes of disability or death due to stroke, heart attack
and kidney failure. Because the etiology of essential hypertension is not known and may be …

Hypertension and related cardiovascular diseases are the leading causes of death in many
countries. The etiology of human essential hypertension is largely unknown. It is highly likely …

Hypertension is the most common chronic disease in the world, yet the precise cause of
elevated blood pressure often cannot be determined. Animal models have been useful for …

Hypertension (HTN) and cardiovascular disease are the most common causes of death in
developed countries. The use of experimental animal models of HTN has provided valuable …

Over the past 50 years various animal models of hypertension have been developed,
predominantly in the rat. In this review we discuss the use of the rat as a model of …

Hypertension, the most common cardiovascular disease is the primary cause of stroke,
coronary artery disease and sudden cardiac death. Many factors are believed to be involved …

Essential hypertension in man is a disease of unknown etiology, for which no animal models
were available until the late 1950s. The first breakthrough was the establishment of the New …

In this review, we outline the application and contribution of transgenic technology to
establishing the genetic basis of blood pressure regulation and its dysfunction. Apart from a …