Recovery of altered neuromuscular junction morphology and muscle function in mdx mice after injury

SJP Pratt, SB Shah, CW Ward, JP Kerr… - Cellular and Molecular …, 2015 - Springer
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease in which
weakness, increased susceptibility to muscle injury, and inadequate repair underlie the …

Pre-and postsynaptic changes in the neuromuscular junction in dystrophic mice

SJP Pratt, AP Valencia, GK Le, SB Shah… - Frontiers in …, 2015 - frontiersin.org
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease in which
weakness, increased susceptibility to muscle injury, and inadequate repair appear to …

Imaging analysis of the neuromuscular junction in dystrophic muscle

SJP Pratt, SR Iyer, SB Shah, RM Lovering - Duchenne Muscular Dystrophy …, 2018 - Springer
Duchenne muscular dystrophy (DMD), caused by the absence of the protein dystrophin, is
characterized as a neuromuscular disease in which muscle weakness, increased …

Effects of in vivo injury on the neuromuscular junction in healthy and dystrophic muscles

SJP Pratt, SB Shah, CW Ward, MP Inacio… - The Journal of …, 2013 - Wiley Online Library
Key points• Strength loss induced by lengthening contractions is typically attributed to
damaged force‐bearing structures within skeletal muscle. Muscle lacking the structural …

Alterations of neuromuscular junctions in Duchenne muscular dystrophy

RM Lovering, SR Iyer, B Edwards, KE Davies - Neuroscience letters, 2020 - Elsevier
The focus of this review is on Duchenne muscular dystrophy (DMD), which is caused by the
absence of the protein dystrophin and is characterized as a neuromuscular disease in which …

Recent insights into neuromuscular junction biology in Duchenne muscular dystrophy: Impacts, challenges, and opportunities

SY Ng, V Ljubicic - EBioMedicine, 2020 - thelancet.com
Duchenne muscular dystrophy (DMD) is the most common and relentless form of muscular
dystrophy. The pleiotropic effects of dystrophin deficiency include remarkable impacts on …

The passive mechanical properties of the extensor digitorum longus muscle are compromised in 2-to 20-mo-old mdx mice

CH Hakim, RW Grange, D Duan - Journal of applied …, 2011 - journals.physiology.org
Muscle rigidity and myotendinous junction (MTJ) deficiency contribute to immobilization in
Duchenne muscular dystrophy (DMD), a lethal disease caused by the absence of …

The effect of lengthening contractions on neuromuscular junction structure in adult and old mice

A Vasilaki, N Pollock, I Giakoumaki… - Age, 2016 - Springer
Skeletal muscles of old mice demonstrate a profound inability to regenerate fully following
damage. Such a failure could be catastrophic to older individuals where muscle loss is …

Mechanically patterned neuromuscular junctions-in-a-dish have improved functional maturation

CL Happe, KP Tenerelli, AK Gromova… - Molecular biology of …, 2017 - Am Soc Cell Biol
Motor neuron (MN) diseases are progressive disorders resulting from degeneration of
neuromuscular junctions (NMJs), which form the connection between MNs and muscle …

Age-related fragmentation of the motor endplate is not associated with impaired neuromuscular transmission in the mouse diaphragm

S Willadt, M Nash, CR Slater - Scientific reports, 2016 - nature.com
As mammals age, their neuromuscular junctions (NMJs) gradually change their form,
acquiring an increasingly fragmented appearance consisting of numerous isolated regions …