An open‐label, dose‐escalation study to assess the safety and efficacy of IL‐22 agonist F‐652 in patients with alcohol‐associated hepatitis

JP Arab, TS Sehrawat, DA Simonetto, VK Verma… - …, 2020 - Wiley Online Library
Background and Aims Interleukin‐22 has beneficial effects on inflammation and impaired
hepatic regeneration that characterize alcohol‐associated hepatitis (AH). F‐652 is a …

Hepatoprotective and anti‐fibrotic functions of interleukin‐22: therapeutic potential for the treatment of alcoholic liver disease

X Kong, D Feng, S Mathews… - … of Gastroenterology and …, 2013 - Wiley Online Library
Abstract Interleukin‐22 (IL‐22) plays a key role in promoting antimicrobial immunity and
tissue repair at barrier surfaces by binding to the receptors IL‐22 R 1, which is generally …

[PDF][PDF] Interleukin‐22 treatment ameliorates alcoholic liver injury in a murine model of chronic‐binge ethanol feeding: role of signal transducer and activator of …

SH Ki, O Park, M Zheng, O Morales‐Ibanez… - …, 2010 - Wiley Online Library
Abstract Interleukin‐22 (IL‐22), a recently identified member of the IL‐10 family of cytokines
that is produced by Th17 and natural killer cells, plays an important role in controlling …

Hepatoprotective and anti‐inflammatory cytokines in alcoholic liver disease

B Gao - Journal of gastroenterology and hepatology, 2012 - Wiley Online Library
The activation of innate immunity by various factors (eg lipopolysaccharide and
complements) plays an important role in initiating and promoting alcoholic liver injury via the …

The interleukin‐17 pathway is involved in human alcoholic liver disease

A Lemmers, C Moreno, T Gustot, R Maréchal… - …, 2009 - Wiley Online Library
Immune dysregulations in alcoholic liver diseases are still unclear, especially regarding
alcoholic hepatitis inflammatory burst. Interleukin‐17 (IL‐17) is known to enhance neutrophil …

Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study

L Spahr, L Rubbia-Brandt, JL Frossard, E Giostra… - Journal of …, 2002 - Elsevier
Background/Aims: The aim of this study is to evaluate the tolerance and effects of infliximab
combined with steroids in severe alcoholic hepatitis (AH). Methods: Twenty patients with …

A pilot study of the safety and tolerability of etanercept in patients with alcoholic hepatitis

KVN Menon, L Stadheim, PS Kamath… - Official journal of the …, 2004 - journals.lww.com
BACKGROUND Alcoholic hepatitis is a cause of major morbidity and mortality, and effective
therapeutic regimens to treat this condition are lacking. Both experimental and clinical …

[PDF][PDF] Pathological functions of interleukin‐22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment

J Zhao, Z Zhang, Y Luan, Z Zou, Y Sun, Y Li, L Jin… - …, 2014 - Wiley Online Library
It is well established that interleukin (IL)‐22 has hepatoprotective and antifibrotic functions in
acute liver injury models; however, its function in patients with liver fibrosis and liver cirrhosis …

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease

HY Ma, G Yamamoto, J Xu, X Liu, D Karin, JY Kim… - Journal of …, 2020 - Elsevier
Background & Aims Chronic alcohol consumption is a leading risk factor for the
development of hepatocellular carcinoma (HCC), which is associated with a marked …

[PDF][PDF] Interleukin‐32 contributes to human nonalcoholic fatty liver disease and insulin resistance

N Dali‐Youcef, M Vix, F Costantino… - Hepatology …, 2019 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder due to increased
accumulation of fat in the liver and in many cases to enhanced inflammation. Although the …