An open‐label, dose‐escalation study to assess the safety and efficacy of IL‐22 agonist F‐652 in patients with alcohol‐associated hepatitis
Background and Aims Interleukin‐22 has beneficial effects on inflammation and impaired
hepatic regeneration that characterize alcohol‐associated hepatitis (AH). F‐652 is a …
hepatic regeneration that characterize alcohol‐associated hepatitis (AH). F‐652 is a …
Hepatoprotective and anti‐fibrotic functions of interleukin‐22: therapeutic potential for the treatment of alcoholic liver disease
X Kong, D Feng, S Mathews… - … of Gastroenterology and …, 2013 - Wiley Online Library
Abstract Interleukin‐22 (IL‐22) plays a key role in promoting antimicrobial immunity and
tissue repair at barrier surfaces by binding to the receptors IL‐22 R 1, which is generally …
tissue repair at barrier surfaces by binding to the receptors IL‐22 R 1, which is generally …
[PDF][PDF] Interleukin‐22 treatment ameliorates alcoholic liver injury in a murine model of chronic‐binge ethanol feeding: role of signal transducer and activator of …
SH Ki, O Park, M Zheng, O Morales‐Ibanez… - …, 2010 - Wiley Online Library
Abstract Interleukin‐22 (IL‐22), a recently identified member of the IL‐10 family of cytokines
that is produced by Th17 and natural killer cells, plays an important role in controlling …
that is produced by Th17 and natural killer cells, plays an important role in controlling …
Hepatoprotective and anti‐inflammatory cytokines in alcoholic liver disease
B Gao - Journal of gastroenterology and hepatology, 2012 - Wiley Online Library
The activation of innate immunity by various factors (eg lipopolysaccharide and
complements) plays an important role in initiating and promoting alcoholic liver injury via the …
complements) plays an important role in initiating and promoting alcoholic liver injury via the …
The interleukin‐17 pathway is involved in human alcoholic liver disease
Immune dysregulations in alcoholic liver diseases are still unclear, especially regarding
alcoholic hepatitis inflammatory burst. Interleukin‐17 (IL‐17) is known to enhance neutrophil …
alcoholic hepatitis inflammatory burst. Interleukin‐17 (IL‐17) is known to enhance neutrophil …
Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study
L Spahr, L Rubbia-Brandt, JL Frossard, E Giostra… - Journal of …, 2002 - Elsevier
Background/Aims: The aim of this study is to evaluate the tolerance and effects of infliximab
combined with steroids in severe alcoholic hepatitis (AH). Methods: Twenty patients with …
combined with steroids in severe alcoholic hepatitis (AH). Methods: Twenty patients with …
A pilot study of the safety and tolerability of etanercept in patients with alcoholic hepatitis
KVN Menon, L Stadheim, PS Kamath… - Official journal of the …, 2004 - journals.lww.com
BACKGROUND Alcoholic hepatitis is a cause of major morbidity and mortality, and effective
therapeutic regimens to treat this condition are lacking. Both experimental and clinical …
therapeutic regimens to treat this condition are lacking. Both experimental and clinical …
[PDF][PDF] Pathological functions of interleukin‐22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment
It is well established that interleukin (IL)‐22 has hepatoprotective and antifibrotic functions in
acute liver injury models; however, its function in patients with liver fibrosis and liver cirrhosis …
acute liver injury models; however, its function in patients with liver fibrosis and liver cirrhosis …
IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease
Background & Aims Chronic alcohol consumption is a leading risk factor for the
development of hepatocellular carcinoma (HCC), which is associated with a marked …
development of hepatocellular carcinoma (HCC), which is associated with a marked …
[PDF][PDF] Interleukin‐32 contributes to human nonalcoholic fatty liver disease and insulin resistance
N Dali‐Youcef, M Vix, F Costantino… - Hepatology …, 2019 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder due to increased
accumulation of fat in the liver and in many cases to enhanced inflammation. Although the …
accumulation of fat in the liver and in many cases to enhanced inflammation. Although the …