Objectives: To determine if T cells in skin lesions in systemic sclerosis (SSc) express the
early activation antigen CD69 that participates in cell-cell interactions. Methods: Skin biopsy …

Objective Fibrotic skin changes in systemic sclerosis (SSc) are preceded by the appearance
of an inflammatory infiltrate rich in T cells. Since no direct comparison with T cells in normal …

Objective T lymphocytes play an important role in systemic sclerosis (SSc), a connective
tissue disease characterized by inflammation, fibrosis, and vascular damage. While their …

Objective Fibrosis is a major contributor to morbidity and mortality in systemic sclerosis
(SSc). T cells are the predominant inflammatory infiltrate in affected tissue and are thought to …

Methods Serum soluble CD30 levels were assayed by a sensitive ELISA in 55 patients with
localized scleroderma, in 15 with systemic sclerosis (SSc), and in 20 healthy controls …

Background The purpose of this study was to investigate the frequency and the distribution
of inflammatory cell infiltrate in two sets of cutaneous biopsies derived from clinically affected …

Introduction Recent accumulating evidence indicates a crucial involvement of macrophage
lineage in the pathogenesis of systemic sclerosis (SSc). To analyze the assembly of the …

Background Abnormalities in lymphocyte surface markers and functions have been
described in systemic sclerosis (SSc), but conflicting results abound, and these studies often …

Despite long-standing recognition of the importance of T cells in systemic sclerosis (SSc;
scleroderma), the role of CD8+ T cells in disease pathogenesis has not been well studied …

Objective To study the role of B lymphocytes in systemic sclerosis (SSc). Methods Peripheral
B cell subpopulations and the production of interleukin‐6 (IL‐6) and transforming growth …