Lithium (Li+) salts are widely used to treat bipolar mood disorders. Recent trials suggest a
potential efficacy also in the treatment of amyotrophic lateral sclerosis and Alzheimer's …

Nephrogenic diabetes insipidus is a clinical sub-type of a diversely expounded disorder,
named diabetes insipidus. It is characterized by inability of the renal cells to sense and …

Lithium is used commonly to treat bipolar mood disorders. In addition to its primary
therapeutic effects in the central nervous system lithium has a number of side effects in the …

Lithium is widely used to treat bipolar disorder. Nephrogenic diabetes insipidus (NDI) is the
most common adverse effect of lithium and occurs in up to 40% of patients. Renal lithium …

Lithium (Li)-induced nephrogenic diabetes insipidus (NDI) has been attributed to the
increased production of renal prostaglandin (PG) E2. Previously we reported that …

Reports of toxic effects on the kidney of lithium treatment emerged very soon after lithium
therapy was introduced. Lithium-induced nephrogenic diabetes insipidus is usually self …

Lithium is the mainstay treatment for patients with bipolar disorder, but it generally causes
nephrogenic diabetes insipidus (NDI), a disorder in which the renal urine concentrating …

Lithium is one of the drugs used widely in the treatment of mood disorders. However, it has a
very narrow therapeutic index and side effects can be seen in many organ systems, one of …

While lithium remains the most efficacious treatment for bipolar disorder, it can cause
significant nephrotoxicity. The molecular mechanisms behind both this process and the …

Lithium has been a valuable treatment for bipolar affective disorders for decades. Clinical
use of lithium, however, has been problematic due to its narrow therapeutic index and …