Molecular symbiosis of CHOP and C/EBPβ isoform LIP contributes to endoplasmic reticulum stress-induced apoptosis

CB Chiribau, F Gaccioli, CC Huang… - … and cellular biology, 2010 - Taylor & Francis
Induction of the transcription factor CHOP (CCAAT-binding homologous protein; GADD 153)
is a critical cellular response for the transcriptional control of endoplasmic reticulum (ER) …

Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion

N Ohoka, T Hattori, M Kitagawa, K Onozaki… - Journal of Biological …, 2007 - ASBMB
C/EBP homologous protein (CHOP) is an endoplasmic reticulum stress-inducible protein
that plays a critical role in the regulation of programmed cell death; however, the regulation …

CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation

M Ubeda, JF Habener - Journal of Biological Chemistry, 2003 - ASBMB
The CAAT/enhancer binding protein homologous transcription factor CHOP, also known as
GADD153, is involved in DNA damage, growth arrest, and the induction of apoptosis after …

C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells

F Allagnat, M Fukaya, TC Nogueira… - Cell Death & …, 2012 - nature.com
Induction of the C/EBP homologous protein (CHOP) is considered a key event for
endoplasmic reticulum (ER) stress-mediated apoptosis. Type 1 diabetes (T1D) is …

Transcription factor C/EBP homologous protein in health and diseases

Y Yang, L Liu, I Naik, Z Braunstein, J Zhong… - Frontiers in …, 2017 - frontiersin.org
C/EBP homologous protein (CHOP), known also as DNA damage-inducible transcript 3 and
as growth arrest and DNA damage-inducible protein 153 (GADD153), is induced in …

Differential control of the CCAAT/enhancer-binding protein β (C/EBPβ) products liver-enriched transcriptional activating protein (LAP) and liver-enriched …

Y Li, E Bevilacqua, CB Chiribau, M Majumder… - Journal of Biological …, 2008 - ASBMB
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers a stress
response program that protects cells early in the response and can lead to apoptosis during …

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

H Zinszner, M Kuroda, XZ Wang… - Genes & …, 1998 - genesdev.cshlp.org
Cellular stress, particularly in response to toxic and metabolic insults that perturb function of
the endoplasmic reticulum (ER stress), is a powerful inducer of the transcription factor …

CHOP gene expression in response to endoplasmic-reticular stress requires NFY interaction with different domains of a conserved DNA-binding element

M Ubeda, JF Habener - Nucleic acids research, 2000 - academic.oup.com
The transcription factor CHOP/GADD153 gene is induced by cellular stress and is involved
in mediating apoptosis. We report the identification of a conserved region in the promoter of …

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153)

XZ Wang, B Lawson, JW Brewer… - … and cellular biology, 1996 - Taylor & Francis
The gene encoding C/EBP-homologous protein (CHOP), also known as growth arrest and
DNA-damage-inducible gene 153 (GADD153), is activated by agents that adversely affect …

C/EBPα or C/EBPα oncoproteins regulate the intrinsic and extrinsic apoptotic pathways by direct interaction with NF-κB p50 bound to the bcl-2 and FLIP gene …

I Paz-Priel, AK Ghosal, J Kowalski, AD Friedman - Leukemia, 2009 - nature.com
CCAAT/enhancer-binding protein α (C/EBPα) is mutated in 10% of acute myeloid leukemias,
resulting in either a truncated protein or an altered leucine zipper (C/EBPαLZ) that prevents …