Abstract γ-glutamylcysteine synthetase (Gcs) is a vital enzyme catalyzing the first and rate
limiting step in the trypanothione biosynthesis pathway, the ATP-dependent ligation of L …

Glutamine synthetase from L. donovani (LdGS) has been identified as a potential
antileishmanial target in our previous report based on biochemical and inhibition studies …

γ-Glutamylcysteine synthetase (γ-GCS) catalyzes the ATP-dependent ligation of L-Glu and L-
Cys, which is the first step in de novo biosynthesis of the tripeptide glutathione. Recently it …

Leishmaniasis is a group of tropical diseases caused by protozoan parasites of the genus
Leishmania. Leishmania donovani is a protozoan parasite that causes visceral …

γ-Glultamylcysteine synthetase (γ-GCS) catalyzes the first step in the de novo biosynthesis
of glutathione. In trypanosomes, glutathione is conjugated to spermidine to form a unique …

Glutamine synthetase (GS) is one of the most important metabolic enzymes which catalyzes
ligation of glutamate and ammonia to form glutamine. Previous studies from our lab had …

The parasitic protozoan Trypanosoma brucei maintains redox balance by synthesizing a
conjugate of glutathione and spermidine termed trypanothione. The first committed step in …

The parasitic protozoa Trypanosoma brucei utilizes a novel cofactor (trypanothione, T (SH)
2), which is a conjugate of GSH and spermidine, to maintain cellular redox balance. γ …

γ-glutamylcysteine synthetase (l-glutamate-l-cysteine ligase, γ-GCS, EC 6.3. 2.2.), the rate
limiting enzyme in glutathione biosynthetic pathway has been analysed in the asexual …

Gamma‐glutamylcysteine synthetase, encoded by the GSH1 gene, is the rate‐limiting
enzyme in the biosynthesis of glutathione and of trypanothione in Leishmania. The …