Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age
AX Xie, N Iguchi, AP Malykhina - American Journal of …, 2024 - journals.physiology.org
Stretch-activated two-pore domain K+ (K2P) channels play important roles in many visceral
organs, including the urinary bladder. The TWIK-related K+ channel TREK-1 is the …
organs, including the urinary bladder. The TWIK-related K+ channel TREK-1 is the …
Altered detrusor contractility and voiding patterns in mice lacking the mechanosensitive TREK-1 channel
RH Pineda, J Hypolite, S Lee, A Carrasco, N Iguchi… - BMC urology, 2019 - Springer
Background Previously published results from our laboratory identified a mechano-gated
two-pore domain potassium channel, TREK-1, as a main mechanosensor in the smooth …
two-pore domain potassium channel, TREK-1, as a main mechanosensor in the smooth …
Response of the human detrusor to stretch is regulated by TREK‐1, a two‐pore‐domain (K2P) mechano‐gated potassium channel
Q Lei, XQ Pan, S Chang, SB Malkowicz… - The Journal of …, 2014 - Wiley Online Library
Key points Mechano‐gated two‐pore‐domain potassium (K2P) channels are expressed in
the human bladder, with TREK‐1 being the predominant functional subunit. TREK‐1 …
the human bladder, with TREK‐1 being the predominant functional subunit. TREK‐1 …
Role of TREK-1 potassium channel in bladder overactivity after partial bladder outlet obstruction in mouse
SA Baker, WJ Hatton, J Han, GW Hennig, FC Britton… - The Journal of …, 2010 - Elsevier
PURPOSE: Mouse models of partial bladder outlet obstruction cause bladder hypertrophy.
Expression of a number of ion channels is altered in hypertrophic detrusor muscle, resulting …
Expression of a number of ion channels is altered in hypertrophic detrusor muscle, resulting …
Altered expression and modulation of the two-pore-domain (K2P) mechanogated potassium channel TREK-1 in overactive human detrusor
RH Pineda, B Nedumaran, J Hypolite… - American Journal …, 2017 - journals.physiology.org
Detrusor overactivity (DO) is the abnormal response of the urinary bladder to physiological
stretch during the filling phase of the micturition cycle. The mechanisms of bladder smooth …
stretch during the filling phase of the micturition cycle. The mechanisms of bladder smooth …
Association of genetic polymorphisms in the pore domains of mechano‐gated TREK‐1 channel with overactive lower urinary tract symptoms in humans
B Nedumaran, RH Pineda, P Rudra… - Neurourology and …, 2019 - Wiley Online Library
Aims Mechanosensitivity of the urinary bladder is regulated by many factors including
mechano‐gated two‐pore domain (K2P, KCNK) potassium channels. TWIK‐related K+ …
mechano‐gated two‐pore domain (K2P, KCNK) potassium channels. TWIK‐related K+ …
Functional expression of mechanosensitive two-pore domain potassium channel in human bladder carcinoma cells
KS PARK, Y Kim - Journal of Biomedical Research, 2013 - pesquisa.bvsalud.org
Bladder cancer is a common cancer in smoking men and may correlate with
mechanosensitive potassium channels because the urinary bladder is a stretch sensing …
mechanosensitive potassium channels because the urinary bladder is a stretch sensing …
Swelling-activated and arachidonic acid-induced currents are TREK-1 in rat bladder smooth muscle cells
M Fukasaku, J Kimura, O Yamaguchi - Fukushima Journal of Medical …, 2016 - jstage.jst.go.jp
Using the perforated patch voltage clamp, we investigated swelling-activated ionic channels
(SACs) in rat urinary bladder smooth muscle cells. Hypo-osmotic (60%) bath solution …
(SACs) in rat urinary bladder smooth muscle cells. Hypo-osmotic (60%) bath solution …
Enhanced expression of TWIK-related arachidonic acid-activated K+ channel in the spinal cord of detrusor overactivity rats after partial bladder outlet obstruction
J Zhang, M Cao, X Wu, Y Chen, W Liang, Y Liang - Bmc Urology, 2015 - Springer
Background Detrusor overactivity (DO) secondary to partial bladder outlet obstruction
(PBOO) is closely associated with alteration of ion channels. The objective of this study is to …
(PBOO) is closely associated with alteration of ion channels. The objective of this study is to …
Altered acetylcholine, bradykinin and cutaneous pressure‐induced vasodilation in mice lacking the TREK1 potassium channel: the endothelial link
The TWIK related K+ channel TREK1 is an important member of the class of two‐pore‐
domain K+ channels. It is a background K+ channel and is regulated by hormones …
domain K+ channels. It is a background K+ channel and is regulated by hormones …