ABSTRACT Introduction: Tyrosine kinase 2 (Tyk2) is a non-receptor tyrosine-protein kinase,
an enzyme that in humans is encoded by the TYK2 gene. Tyk2, together with three other …

ABSTRACT Introduction Tyrosine kinase 2 (TYK2) is a member of the JAK family class of
kinases that is responsible for mediating the immune response to IL-12, IL-23, and IFNα. The …

Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family that regulates signal
transduction downstream of receptors for the IL-23/IL-12 pathways and type I interferon …

Janus kinases (JAKs) are central components in cytokine signaling pathways. A number of
small molecule JAK inhibitors have been approved to treat a wide range of inflammatory and …

JAKs are intracellular protein tyrosine kinases that, through activation of STATs, are
responsible for signal transduction pathways that regulate cellular responses to numerous …

JAK inhibitors impact multiple cytokine pathways simultaneously, enabling high efficacy in
treating complex diseases such as cancers and immune-mediated disorders. However, their …

A therapeutic rationale is proposed for the treatment of inflammatory diseases, such as
psoriasis and inflammatory bowel diseases (IBD), by selective targeting of TYK2. Hit triage …

TYK2 is an emerging drug target for various human autoimmune diseases. However,
discovery of selective TYK2 inhibitor over other JAK family members (ie, JAK1, 2, 3) by …

A member of the Janus kinase (JAK) family, Tyrosine Kinase 2 (TYK2), is crucial in
mediating various cytokine-signaling pathways such as interleukin-23 (IL23), interleukin-12 …

Herein we report our lead optimization effort to identify potent, selective, and orally
bioavailable TYK2 inhibitors, starting with lead molecule 3. We used structure-based design …